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    CBLC Cbl proto-oncogene C [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713112, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CBLCprovided by VGNC
    Official Full Name
    Cbl proto-oncogene Cprovided by VGNC
    Primary source
    VGNC:VGNC:108489
    Locus tag
    EGK_10730
    See related
    Ensembl:ENSMMUG00000049451
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CBLC in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (44814744..44838016)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (40083388..40106398)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene BCL3 transcription coactivator Neighboring gene small nucleolar RNA SNORA70 Neighboring gene basal cell adhesion molecule Neighboring gene nectin cell adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL-C
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence c
    Cbl proto-oncogene, E3 ubiquitin protein ligase C
    XP_001109370.1
    XP_014979722.2
    XP_014979723.2
    XP_014979724.1
    XP_028694946.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      44814744..44838016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015124237.2 → XP_014979723.2  E3 ubiquitin-protein ligase CBL-C isoform X3

      Conserved Domains (4) summary
      COG5236
      Location:299 → 385
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam02262
      Location:16 → 145
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:149 → 232
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cl15255
      Location:226 → 331
      SH2; Src homology 2 (SH2) domain

    2. XM_028839113.1 → XP_028694946.1  E3 ubiquitin-protein ligase CBL-C isoform X4

      Conserved Domains (4) summary
      cd09920
      Location:226 → 322
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02262
      Location:16 → 145
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd16710
      Location:345 → 397
      RING-HC_Cbl-c; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-c and similar proteins
      pfam02761
      Location:149 → 232
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    3. XM_015124238.2 → XP_014979724.1  E3 ubiquitin-protein ligase CBL-C isoform X5

      UniProtKB/TrEMBL
      A0A5F8AHX9
      Related
      ENSMMUP00000076595.1, ENSMMUT00000083242.1
      Conserved Domains (3) summary
      pfam02262
      Location:16 → 145
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:149 → 232
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cl15255
      Location:226 → 331
      SH2; Src homology 2 (SH2) domain

    4. XM_015124236.2 → XP_014979722.2  E3 ubiquitin-protein ligase CBL-C isoform X1

      Conserved Domains (4) summary
      cd09920
      Location:226 → 322
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02262
      Location:16 → 145
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd16710
      Location:345 → 397
      RING-HC_Cbl-c; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-c and similar proteins
      pfam02761
      Location:149 → 232
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    5. XM_001109370.4 → XP_001109370.1  E3 ubiquitin-protein ligase CBL-C isoform X2

      See identical proteins and their annotated locations for XP_001109370.1

      UniProtKB/TrEMBL
      A0A5F8A6T2, A0A8J8XPX7, F7FKP6
      Related
      ENSMMUP00000072666.1, ENSMMUT00000100227.1
      Conserved Domains (4) summary
      cd09920
      Location:226 → 322
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:351 → 393
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02262
      Location:16 → 145
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:149 → 232
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RNA

    1. XR_003724951.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials