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    CASP8 caspase 8 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 702781, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CASP8provided by VGNC
    Official Full Name
    caspase 8provided by VGNC
    Primary source
    VGNC:VGNC:70547
    See related
    Ensembl:ENSMMUG00000031296
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CASP8 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (88499208..88559203)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (82739527..82798781)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD like apoptosis regulator Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene caspase 10 Neighboring gene protein shisa-5 pseudogene Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene SCY1-like protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-8
    XP_014966130.1
    XP_014966131.1
    XP_014966132.1
    XP_014966134.1
    XP_014966136.1
    XP_014966137.1
    XP_014966138.1
    XP_028686809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      88499208..88559203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015110650.2 → XP_014966136.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Related
      ENSMMUP00000037891.2, ENSMMUT00000044868.3
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_015110651.2 → XP_014966137.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_015110648.2 → XP_014966134.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_015110652.2 → XP_014966138.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    5. XM_015110644.2 → XP_014966130.1  caspase-8 isoform X1

      UniProtKB/TrEMBL
      F7C587
      Related
      ENSMMUP00000037892.3, ENSMMUT00000044869.3
      Conserved Domains (3) summary
      cd00032
      Location:242 → 494
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:20 → 101
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:115 → 197
      DD; Death Domain Superfamily of protein-protein interaction domains

    6. XM_028830976.1 → XP_028686809.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    7. XM_015110646.2 → XP_014966132.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains

    8. XM_015110645.2 → XP_014966131.1  caspase-8 isoform X2

      UniProtKB/TrEMBL
      F7C564, F7C587, F7C594
      Related
      ENSMMUP00000037895.3, ENSMMUT00000044872.3
      Conserved Domains (3) summary
      cd00032
      Location:225 → 477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 → 180
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein
    Heading Accession and Version

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