HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: HADHAprovided by VGNC
Official Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:103823
See related: Ensembl:ENSMMUG00000004380
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	13	NC_041766.1 (82728606..82785363)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	13	NC_027905.1 (26455334..26512110, complement)

Chromosome 13 - NC_041766.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH47828 (e-PCR)
- UniSTS:33830

RH103795 (e-PCR)
- UniSTS:98120

SHGC-34066 (e-PCR)
- UniSTS:39530

RH17550 (e-PCR)
- UniSTS:87432

D12S1229E (e-PCR)
- UniSTS:151476

HADHA-I16 (e-PCR)
- UniSTS:467707

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed
enables enoyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: trifunctional enzyme subunit alpha, mitochondrial

Names: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

NP_001252819.1

EC 1.1.1.211

EC 4.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001265890.1 → NP_001252819.1 trifunctional enzyme subunit alpha, mitochondrial

See identical proteins and their annotated locations for NP_001252819.1

Status: PROVISIONAL

Source sequence(s)

JV045122

UniProtKB/TrEMBL

F7FRK6, I0FL67

Related

ENSMMUP00000072365.1, ENSMMUT00000088885.1

Conserved Domains (4) summary

cd06558
Location:41 → 251

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

TIGR02441
Location:27 → 762

fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial

pfam00725
Location:544 → 639

3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

pfam02737
Location:363 → 541

3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain