Stard5 StAR related lipid transfer domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard5provided by MGI
Official Full Name: StAR related lipid transfer domain containing 5provided by MGI
Primary source: MGI:MGI:2156765
See related: Ensembl:ENSMUSG00000046027 AllianceGenome:MGI:2156765
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D7Ertd152e; 2310058G22Rik
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cholesterol import. Is expressed in embryo; liver; metanephros; and small intestine. Orthologous to human STARD5 (StAR related lipid transfer domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 30.6), liver adult (RPKM 26.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 47.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83281225..83291536)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (83632017..83642328)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis.
Title: StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis.
The studies show that StarD5 is a stress-responsive protein that regulates PM cholesterol and intracellular cholesterol homeostasis.
Title: StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.
Data support STARD5 functioning in kidney, specifically within proximal tubule cells, and suggest a role in ER-associated cholesterol transport.
Title: Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules.
StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions
Title: Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

AI607880 (e-PCR)
- UniSTS:179603

RH126299 (e-PCR)
- UniSTS:163007

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	ISA Inferred from Sequence Alignment more info	PubMed
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol import	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol import	IEA Inferred from Electronic Annotation more info
involved_in cholesterol import	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 5

Names: 18B7-T7(GS); START domain-containing protein 5; StAR-related lipid transfer (START) domain containing 5; StAR-related protein 1-4E; StAR-related protein p3-15E/p3-16E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023377.4 → NP_075866.2 stAR-related lipid transfer protein 5

See identical proteins and their annotated locations for NP_075866.2

Status: PROVISIONAL

Source sequence(s)

BC058226

Consensus CDS

CCDS21411.1

UniProtKB/Swiss-Prot

Q9CQY0, Q9EPQ6, Q9EPQ7

Related

ENSMUSP00000074872.8, ENSMUST00000075418.15

Conserved Domains (1) summary

cl14643
Location:6 → 211

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily