Fbl fibrillarin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fblprovided by MGI
Official Full Name: fibrillarinprovided by MGI
Primary source: MGI:MGI:95486
See related: Ensembl:ENSMUSG00000046865 AllianceGenome:MGI:95486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FIB; FLRN; RNU3IP1
Summary: Enables RNA binding activity. Acts upstream of or within sno(s)RNA metabolic process. Located in Cajal body and granular component. Is expressed in several structures, including central nervous system; early embryo; oocyte; retina; and submandibular gland primordium. Orthologous to human FBL (fibrillarin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 132.0), liver E14 (RPKM 128.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.67 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27868293..27878701)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28168893..28179269)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
Title: Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K
Title: [Analysis of the Localization of Fibrillarin and Sites of Pre-rRNA Synthesis in the Nucleolus-Like Bodies of Mouse GV Oocytes after Mild Treatment with Proteinase K].
SUV39h1 associated with HP1 beta in fibrillarin-positive nucleolar regions.
Title: SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions.
massive apoptosis was observed in early Fibrillarin(-/-) embryos, showing that fibrillarin is essential for development
Title: Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse.
Results suggest that proteasome-dependent processing of fibrillarin occurs upon mercury induction.
Title: Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen.
This splicing factor was more abundant in hepatocyte nuclei of mice fed genetically-modified soybeans than in control mice.
Title: Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125326 (e-PCR)
- UniSTS:162148

MARC_26184-26185:1030717529:1 (e-PCR)
- UniSTS:268975

NoName (e-PCR)
- UniSTS:237553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIID-class transcription factor complex binding	IEA Inferred from Electronic Annotation more info
enables TFIID-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA 2'-O-ribose methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AQ104 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AQ104 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AQ104 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables rRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in box C/D sno(s)RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in rRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sno(s)RNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in snoRNA localization	IEA Inferred from Electronic Annotation more info
involved_in snoRNA localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of box C/D methylation guide snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in dense fibrillar component	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in granular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rRNA 2'-O-methyltransferase fibrillarin

Names: U6 snRNA 2'-O-methyltransferase fibrillarin; histone-glutamine methyltransferase; nucleolar protein 1

NP_001399349.1

EC 2.1.1.-

NP_032017.2

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412420.1 → NP_001399349.1 rRNA 2'-O-methyltransferase fibrillarin isoform 2

Status: VALIDATED

Source sequence(s)

AC141883
NM_007991.4 → NP_032017.2 rRNA 2'-O-methyltransferase fibrillarin isoform 1

See identical proteins and their annotated locations for NP_032017.2

Status: VALIDATED

Source sequence(s)

AC141883

Consensus CDS

CCDS21036.1

UniProtKB/Swiss-Prot

P35550, Q99L58

UniProtKB/TrEMBL

Q3UJS2

Related

ENSMUSP00000037613.7, ENSMUST00000042405.8

Conserved Domains (1) summary

PTZ00146
Location:88 → 326

PTZ00146; fibrillarin; Provisional