Elob elongin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elobprovided by MGI
Official Full Name: elongin Bprovided by MGI
Primary source: MGI:MGI:1914923
See related: Ensembl:ENSMUSG00000055839 AllianceGenome:MGI:1914923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tceb2; 0610040H15Rik
Summary: Predicted to enable transcription coactivator activity; transcription corepressor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in target-directed miRNA degradation and transcription initiation at RNA polymerase II promoter. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in brain; brown fat; dorsal root ganglion; genitourinary system; and limb. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 383.1), large intestine adult (RPKM 213.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 A3.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24043714..24048083, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23824740..23829109, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that post-transcriptional regulation of Elongin B occurs in the testis, which is a common phenomenon during male germ cell development. As a major binding partner of SPAG16S, Elongin B may play an important role in spermatogenesis by modulating RNA maturation.
Title: Elongin B is a binding partner of the male germ cell nuclear speckle protein sperm-associated antigen 16S (SPAG16S) and is regulated post-transcriptionally in the testis.
EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape.
Title: EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells.
Title: EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.
Crystal structure shows interaction between SOCS2-elongin BC and Cullin-5.
Title: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
both P-TEFb activity and H1 phosphorylation are necessary for the full differentiation of C2C12 myoblasts into myotubes.
Title: Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation.
Elongin B/C recruitment regulates substrate binding by CIS
Title: Elongin B/C recruitment regulates substrate binding by CIS.
SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation.
Title: The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in target-directed miRNA degradation	IEA Inferred from Electronic Annotation more info
involved_in target-directed miRNA degradation	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul5-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of VCB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCB complex	IEA Inferred from Electronic Annotation more info
part_of VCB complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of elongin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongin complex	IDA Inferred from Direct Assay more info	PubMed
part_of elongin complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: elongin-B

Names: 18 kDa, elongin B; RNA polymerase II transcription factor SIII subunit B; SIII p18; elongin 18 kDa subunit; transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B); transcription elongation factor B polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026305.2 → NP_080581.1 elongin-B

See identical proteins and their annotated locations for NP_080581.1

Status: PROVISIONAL

Source sequence(s)

AK002868

Consensus CDS

CCDS57055.1

UniProtKB/Swiss-Prot

P62869, Q63529, Q80W20

Related

ENSMUSP00000066210.6, ENSMUST00000069579.7

Conserved Domains (1) summary

cd01788
Location:2 → 102

Ubl_ElonginB; ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins