Abtb2 ankyrin repeat and BTB domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abtb2provided by MGI
Official Full Name: ankyrin repeat and BTB domain containing 2provided by MGI
Primary source: MGI:MGI:2139365
See related: Ensembl:ENSMUSG00000032724 AllianceGenome:MGI:2139365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein heterodimerization activity. Acts upstream of or within cellular response to toxic substance. Is expressed in several structures, including central nervous system; hindlimb long bone; limb segment; respiratory system cartilage; and sensory organ. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 34.5), adrenal adult (RPKM 27.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.43 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103396655..103548768)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (103566310..103718423)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ankyrin repeat and BTB/POZ domain containing protein-2
Title: Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BM384314 (e-PCR)
- UniSTS:260936

AW539457 (e-PCR)
- UniSTS:178663

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ankyrin repeat and BTB/POZ domain-containing protein 2

Names: ankyrin repeat and BTB (POZ) domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178890.3 → NP_849221.2 ankyrin repeat and BTB/POZ domain-containing protein 2

See identical proteins and their annotated locations for NP_849221.2

Status: PROVISIONAL

Source sequence(s)

BC054399

Consensus CDS

CCDS16479.1

UniProtKB/Swiss-Prot

Q7TQI7

UniProtKB/TrEMBL

Q3T9J9, Q3U8L9

Related

ENSMUSP00000075566.4, ENSMUST00000076212.4

Conserved Domains (8) summary

smart00225
Location:845 → 946

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:516 → 670

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14821
Location:946 → 990

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:836 → 939

BTB; BTB/POZ domain

pfam12796
Location:526 → 633

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:498 → 542

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:524 → 565

ANK; ANK repeat [structural motif]

cl23907
Location:194 → 242

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...