Zeb1 zinc finger E-box binding homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zeb1provided by MGI
Official Full Name: zinc finger E-box binding homeobox 1provided by MGI
Primary source: MGI:MGI:1344313
See related: Ensembl:ENSMUSG00000024238 AllianceGenome:MGI:1344313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tw; BZP; ZEB; MEB1; Nil2; Tcf8; AREB6; TCF-8; Tcf18; Zfhep; Zfx1a; Zfhx1a; Zfx1ha; [delta]EF1; 3110032K11Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; negative regulation of keratinocyte proliferation; and regulation of T cell differentiation in thymus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.2), limb E14.5 (RPKM 8.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 4.42 cM; 18 A1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (5591330..5775468)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (5591327..5775468)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Title: Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition.
Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis.
Title: Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis.
The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.
Title: The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.
ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
Title: ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion.
Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.
Title: Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.
The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.
Title: The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.
PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma.
Title: PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma.
The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells.
Title: The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells.
LncRNA LINC00667 gets involved in clear cell renal cell carcinoma development and chemoresistance by regulating the miR-143-3p/ZEB1 axis.
Title: LncRNA LINC00667 gets involved in clear cell renal cell carcinoma development and chemoresistance by regulating the miR-143-3p/ZEB1 axis.
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Title: ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.

Submit: New GeneRIF Correction See all GeneRIFs (116)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (6) 1 citation
Spontaneous (1) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U26259 (e-PCR)
- UniSTS:125702

NoName (e-PCR)
- UniSTS:237733

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger E-box-binding homeobox 1

Names: transcription factor 8; twirler; zinc finger homeobox protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360981.1 → NP_001347910.1 zinc finger E-box-binding homeobox 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC127028, AC138619

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (4) summary

smart00389
Location:554 → 590

HOX; Homeodomain

sd00017
Location:867 → 887

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:203 → 225

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:907 → 932

zf-H2C2_2; Zinc-finger double domain
NM_001360982.1 → NP_001347911.1 zinc finger E-box-binding homeobox 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC127028, AC138619

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
NM_011546.3 → NP_035676.1 zinc finger E-box-binding homeobox 1 isoform 1

See identical proteins and their annotated locations for NP_035676.1

Status: VALIDATED

Source sequence(s)

AC127028, AK034821, BC139769, BE852657

Consensus CDS

CCDS29039.1

UniProtKB/Swiss-Prot

A4QPD2, Q62519, Q64318

UniProtKB/TrEMBL

A4QPD1

Related

ENSMUSP00000025081.6, ENSMUST00000025081.13

Conserved Domains (4) summary

smart00389
Location:571 → 607

HOX; Homeodomain

sd00017
Location:884 → 904

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:220 → 242

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:924 → 949

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

5591330..5775468

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250410.2 → XP_030106270.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250409.2 → XP_030106269.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250411.2 → XP_030106271.1 zinc finger E-box-binding homeobox 1 isoform X4

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (4) summary

smart00389
Location:504 → 540

HOX; Homeodomain

sd00017
Location:817 → 837

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:153 → 175

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:857 → 882

zf-H2C2_2; Zinc-finger double domain
XM_036161065.1 → XP_036016958.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250401.1 → XP_030106261.1 zinc finger E-box-binding homeobox 1 isoform X1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_030250405.2 → XP_030106265.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250400.2 → XP_030106260.1 zinc finger E-box-binding homeobox 1 isoform X1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_030250406.2 → XP_030106266.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161061.1 → XP_036016954.1 zinc finger E-box-binding homeobox 1 isoform X1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_006525769.4 → XP_006525832.1 zinc finger E-box-binding homeobox 1 isoform X1

See identical proteins and their annotated locations for XP_006525832.1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_036161062.1 → XP_036016955.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161059.1 → XP_036016952.1 zinc finger E-box-binding homeobox 1 isoform X1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_030250407.2 → XP_030106267.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250404.2 → XP_030106264.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161068.1 → XP_036016961.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161067.1 → XP_036016960.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_030250402.2 → XP_030106262.1 zinc finger E-box-binding homeobox 1 isoform X2

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (4) summary

smart00389
Location:557 → 593

HOX; Homeodomain

sd00017
Location:870 → 890

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:206 → 228

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:910 → 935

zf-H2C2_2; Zinc-finger double domain
XM_030250399.2 → XP_030106259.1 zinc finger E-box-binding homeobox 1 isoform X1

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:877 → 897

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:213 → 235

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:917 → 942

zf-H2C2_2; Zinc-finger double domain
XM_036161066.1 → XP_036016959.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161069.1 → XP_036016962.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161063.1 → XP_036016956.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161064.1 → XP_036016957.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain
XM_036161070.1 → XP_036016963.1 zinc finger E-box-binding homeobox 1 isoform X3

UniProtKB/TrEMBL

A4QPD1

Conserved Domains (3) summary

sd00017
Location:828 → 848

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:164 → 186

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:868 → 893

zf-H2C2_2; Zinc-finger double domain