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    Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctla2aprovided by MGI
    Official Full Name
    cytotoxic T lymphocyte-associated protein 2 alphaprovided by MGI
    Primary source
    MGI:MGI:88554
    See related
    Ensembl:ENSMUSG00000044258 AllianceGenome:MGI:88554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctla-2a
    Summary
    Acts upstream of or within negative regulation of inflammatory response; negative regulation of protein processing; and regulation of regulatory T cell differentiation. Located in dendrite. Is expressed in several structures, including blood; cerebral cortex; extraembryonic component; genitourinary system; and lung. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 179.4) and lung adult (RPKM 12.9) See more
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    Genomic context

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    See Ctla2a in Genome Data Viewer
    Location:
    13 B2; 13 32.56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61081969..61084439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60934155..60936625, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytotoxic T lymphocyte-associated protein 2 beta Neighboring gene trophoblast specific protein beta Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40976 Neighboring gene predicted gene, 40975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dendritic and axonal localization of cytotoxic T-lymphocyte antigen-2 alpha protein in mouse brain. Luziga C, et al. Brain Res, 2008 Apr 14. PMID 18342295
    2. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Zhang L, et al. Cell Signal, 2011 Oct. PMID 21620962, Free PMC Article
    3. Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions. Denizot F, et al. Eur J Immunol, 1989 Apr. PMID 2786470
    4. Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain. Luziga C, et al. Acta Histochem, 2016 Sep. PMID 27586811
    5. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. Sugita S, et al. J Immunol, 2009 Oct 15. PMID 19801522

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP
      Title: Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
    2. that the fine equilibrium between synthesis and secretion of cathespin L and CTLA-2alpha is part of the brain processes to maintain normal growth and development
      Title: Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.
    3. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
      Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
    4. cAMP increases CTLA-2alpha expression in murine lymphoma and cardiac fibroblasts, and this increase in CTLA-2alpha contributes to cAMP/PKA-promoted apoptosis by mechanisms that are independent of the ability of CTLA-2alpha to inhibit cathepsin L.
      Title: Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein CTLA-2-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145799.1 → NP_001139271.1  protein CTLA-2-alpha isoform b

      See identical proteins and their annotated locations for NP_001139271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AA451288, AK018801, AK132290
      UniProtKB/TrEMBL
      A0A286YDF0
      Conserved Domains (1) summary
      smart00848
      Location:16 → 74
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    2. NM_007796.2 → NP_031822.2  protein CTLA-2-alpha isoform a precursor

      See identical proteins and their annotated locations for NP_031822.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK132290, AK167433, BB574774
      Consensus CDS
      CCDS49290.1
      UniProtKB/Swiss-Prot
      P12399, Q91V07
      UniProtKB/TrEMBL
      A0A286YDF0
      Related
      ENSMUSP00000021880.10, ENSMUST00000021880.10
      Conserved Domains (1) summary
      smart00848
      Location:40 → 98
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      61081969..61084439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12399.2 GenPept UniProtKB/Swiss-Prot:P12399

    Gene LinkOut

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