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    Fasl Fas ligand [ Mus musculus (house mouse) ]

    Gene ID: 14103, updated on 14-Jan-2025

    Summary

    Official Symbol
    Faslprovided by MGI
    Official Full Name
    Fas ligandprovided by MGI
    Primary source
    MGI:MGI:99255
    See related
    Ensembl:ENSMUSG00000000817 AllianceGenome:MGI:99255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1
    Summary
    Predicted to enable cytokine activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Fasl in Genome Data Viewer
    Location:
    1 H2.1; 1 69.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161608260..161616064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161780691..161788495, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5837 Neighboring gene glutamic pyruvic transaminase, soluble pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7765 Neighboring gene STARR-seq mESC enhancer starr_02829 Neighboring gene predicted gene, 31869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163734643-163734826 Neighboring gene SUN domain containing ossification factor Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10050 Neighboring gene STARR-positive B cell enhancer ABC_E2578 Neighboring gene STARR-positive B cell enhancer ABC_E7766 Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene predicted gene, 31925

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (3) 
    • Spontaneous (2)  1 citation
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables death receptor binding  
    enables death receptor binding  
    enables tumor necrosis factor receptor binding  
    enables tumor necrosis factor receptor binding  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in T cell apoptotic process  
    involved_in T cell apoptotic process  
    acts_upstream_of_or_within apoptotic signaling pathway PubMed 
    involved_in apoptotic signaling pathway  
    involved_in cellular response to type II interferon  
    involved_in endosomal lumen acidification  
    involved_in endosomal lumen acidification  
    involved_in extrinsic apoptotic signaling pathway  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in inflammatory cell apoptotic process  
    involved_in inflammatory cell apoptotic process  
    involved_in intracellular chloride ion homeostasis  
    involved_in intracellular chloride ion homeostasis  
    involved_in necroptotic process  
    involved_in necroptotic signaling pathway  
    involved_in necroptotic signaling pathway  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface  
    involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface  
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum PubMed 
    involved_in response to growth factor  
    involved_in response to lipopolysaccharide  
    acts_upstream_of_or_within retinal cell programmed cell death PubMed 
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in caveola  
    located_in caveola  
    located_in cell surface PubMed 
    located_in cytoplasmic vesicle lumen  
    located_in external side of plasma membrane PubMed 
    located_in extracellular exosome  
    located_in extracellular exosome  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in lysosomal lumen  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 6
    Names
    CD95 ligand
    Fas antigen ligand
    Fas ligand (TNF superfamily, member 6)
    generalized lymphoproliferative disease
    tumor necrosis factor ligand 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205243.1NP_001192172.1  tumor necrosis factor ligand superfamily member 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC164414, AF288572
      UniProtKB/TrEMBL
      Q99PH8
    2. NM_010177.4NP_034307.1  tumor necrosis factor ligand superfamily member 6 isoform 1

      See identical proteins and their annotated locations for NP_034307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK040139
      Consensus CDS
      CCDS15418.1
      UniProtKB/Swiss-Prot
      P41047, Q61217, Q9R1F2
      UniProtKB/TrEMBL
      Q544E9, Q7TMV9
      Related
      ENSMUSP00000000834.3, ENSMUST00000000834.4
      Conserved Domains (1) summary
      cd00184
      Location:144277
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      161608260..161616064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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