Cisd3 CDGSH iron sulfur domain 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cisd3provided by MGI
Official Full Name: CDGSH iron sulfur domain 3provided by MGI
Primary source: MGI:MGI:101788
See related: Ensembl:ENSMUSG00000078695 AllianceGenome:MGI:101788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mel13; Mel-13
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Located in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 67.3), duodenum adult (RPKM 51.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97576291..97579451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97685465..97688625)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
Title: FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: CDGSH iron-sulfur domain-containing protein 3, mitochondrial

Names: melanoma nuclear protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085500.3 → NP_001078969.2 CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor

See identical proteins and their annotated locations for NP_001078969.2

Status: VALIDATED

Source sequence(s)

AA987107, AI414532, BC056217

Consensus CDS

CCDS48896.1

UniProtKB/Swiss-Prot

B1AR11, B1AR12, B1AR13

UniProtKB/TrEMBL

Z4YKM2

Related

ENSMUSP00000103209.3, ENSMUST00000107583.3

Conserved Domains (2) summary

pfam09360
Location:56 → 85

zf-CDGSH; Iron-binding zinc finger CDGSH type

cl02748
Location:93 → 129

zf-CDGSH; Iron-binding zinc finger CDGSH type
NM_001364153.1 → NP_001351082.1 CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

AL596123, BC147739

UniProtKB/TrEMBL

B3DFI8

Conserved Domains (1) summary

pfam09360
Location:136 → 165

zf-CDGSH; Iron-binding zinc finger CDGSH type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97576291..97579451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533029.3 → XP_006533092.1 CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform X1

UniProtKB/TrEMBL

B3DFI8

Conserved Domains (1) summary

pfam09360
Location:117 → 146

zf-CDGSH; Iron-binding zinc finger CDGSH type