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    Cfap74 cilia and flagella associated protein 74 [ Mus musculus (house mouse) ]

    Gene ID: 544678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap74provided by MGI
    Official Full Name
    cilia and flagella associated protein 74provided by MGI
    Primary source
    MGI:MGI:1917130
    See related
    Ensembl:ENSMUSG00000078490 AllianceGenome:MGI:1917130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530045M11; 2010015L04Rik
    Summary
    Predicted to be involved in axoneme assembly. Predicted to be located in axoneme; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CFAP74 (cilia and flagella associated protein 74). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 12.3), thymus adult (RPKM 2.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap74 in Genome Data Viewer
    Location:
    4 E2; 4 86.17 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155493647..155551280)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155392099..155466823)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12256 Neighboring gene protein kinase C, zeta Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit delta Neighboring gene STARR-positive B cell enhancer ABC_E4738 Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene guanine nucleotide binding protein (G protein), beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1751

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 74

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166029.1 → NP_001159501.1  cilia- and flagella-associated protein 74 isoform 2

      See identical proteins and their annotated locations for NP_001159501.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the presence and absence of exons in its 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (2) with a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC056495, CD776645, CJ049960
      Consensus CDS
      CCDS51402.1
      UniProtKB/TrEMBL
      G3UWF6
      Related
      ENSMUSP00000131899.2, ENSMUST00000123952.9

    2. NM_001368738.1 → NP_001355667.1  cilia- and flagella-associated protein 74 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670227
      Consensus CDS
      CCDS89870.1
      UniProtKB/TrEMBL
      A0A571BED3, A0A571BG73
      Related
      ENSMUSP00000158718.2, ENSMUST00000238423.2
      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    3. NM_177674.5 → NP_808342.3  cilia- and flagella-associated protein 74 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK134858, AL670227, CJ049960
      UniProtKB/Swiss-Prot
      Q3UY96
      Related
      ENSMUST00000094408.10
      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155493647..155551280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164244.1 → XP_036020137.1  cilia- and flagella-associated protein 74 isoform X2

      UniProtKB/Swiss-Prot
      A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
      Conserved Domains (1) summary
      pfam17380
      Location:93 → 418
      DUF5401; Family of unknown function (DUF5401)

    2. XM_036164243.1 → XP_036020136.1  cilia- and flagella-associated protein 74 isoform X1

      UniProtKB/Swiss-Prot
      A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
      Conserved Domains (1) summary
      pfam17380
      Location:93 → 418
      DUF5401; Family of unknown function (DUF5401)

    3. XM_036164242.1 → XP_036020135.1  cilia- and flagella-associated protein 74 isoform X1

      UniProtKB/Swiss-Prot
      A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
      Conserved Domains (1) summary
      pfam17380
      Location:93 → 418
      DUF5401; Family of unknown function (DUF5401)

    4. XM_036164245.1 → XP_036020138.1  cilia- and flagella-associated protein 74 isoform X3

      UniProtKB/Swiss-Prot
      A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
      Conserved Domains (1) summary
      pfam17380
      Location:93 → 418
      DUF5401; Family of unknown function (DUF5401)

    5. XM_036164246.1 → XP_036020139.1  cilia- and flagella-associated protein 74 isoform X4

      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    6. XM_006539054.4 → XP_006539117.1  cilia- and flagella-associated protein 74 isoform X6

      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    7. XM_006539053.4 → XP_006539116.1  cilia- and flagella-associated protein 74 isoform X5

      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    8. XM_011250302.3 → XP_011248604.1  cilia- and flagella-associated protein 74 isoform X8

      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional

    9. XM_036164247.1 → XP_036020140.1  cilia- and flagella-associated protein 74 isoform X7

      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 374
      PTZ00121; MAEBL; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UY96.3 GenPept UniProtKB/Swiss-Prot:Q3UY96

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