Arrdc5 arrestin domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arrdc5provided by MGI
Official Full Name: arrestin domain containing 5provided by MGI
Primary source: MGI:MGI:1924170
See related: Ensembl:ENSMUSG00000073380 AllianceGenome:MGI:1924170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700013E09Rik
Summary: Predicted to be involved in protein transport. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC5 (arrestin domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 106.5) See more
Orthologs: human all
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Genomic context

Location:: 17 29.26 cM; 17 D

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56601111..56607262, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56294111..56300286, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.
Title: ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1.
ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.
Title: ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arrestin domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029799.2 → NP_084075.1 arrestin domain-containing protein 5

See identical proteins and their annotated locations for NP_084075.1

Status: VALIDATED

Source sequence(s)

AC026385

Consensus CDS

CCDS28902.1

UniProtKB/Swiss-Prot

Q497K5

Related

ENSMUSP00000094906.2, ENSMUST00000097303.3

Conserved Domains (2) summary

pfam02752
Location:170 → 304

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:13 → 128

Arrestin_N; Arrestin (or S-antigen), N-terminal domain