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    H2-Oa histocompatibility 2, O region alpha locus [ Mus musculus (house mouse) ]

    Gene ID: 15001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2-Oaprovided by MGI
    Official Full Name
    histocompatibility 2, O region alpha locusprovided by MGI
    Primary source
    MGI:MGI:95924
    See related
    Ensembl:ENSMUSG00000024334 AllianceGenome:MGI:95924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2Oa
    Summary
    Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and regulation of T cell differentiation. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in several structures, including central nervous system; cornea; genitourinary system; palatal shelf; and salivary gland primordium. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 116.7), thymus adult (RPKM 40.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See H2-Oa in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34311353..34314286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34092379..34095234)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11636 Neighboring gene STARR-positive B cell enhancer ABC_E5596 Neighboring gene histocompatibility 2, P region beta locus Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene STARR-positive B cell enhancer ABC_E11637 Neighboring gene STARR-positive B cell enhancer ABC_E7522 Neighboring gene STARR-seq mESC enhancer starr_42423 Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34266262-34266415 Neighboring gene STARR-positive B cell enhancer ABC_E117 Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene histocompatibility 2, class II, locus Mb2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H2-O inhibits presentation of bacterial superantigens, but not endogenous self antigens. Qi L, et al. J Immunol, 2001 Aug 1. PMID 11466355
    2. Immunodeficiency and autoimmunity in H2-O-deficient mice. Gu Y, et al. J Immunol, 2013 Jan 1. PMID 23209323
    3. H2-O expression in primary dendritic cells. Chen X, et al. J Immunol, 2006 Mar 15. PMID 16517723
    4. Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function. Fallas JL, et al. J Immunol, 2007 Feb 1. PMID 17237397
    5. Analysis of H2-O influence on antigen presentation by B cells. Alfonso C, et al. J Immunol, 2003 Sep 1. PMID 12928379

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proper development of long-lived memory CD4 T cells requires HLA-DO function.
      Title: Proper development of long-lived memory CD4 T cells requires HLA-DO function.
    2. Mouse MHC class II chaperone H2-O antigen affects the repertoire of presented self-peptides by B cells and thymic epithelium. H2-O induces differential effects on epitope presentation and thymic selection, thereby altering CD4 T-cell precursor frequencies. Lack of H2-O increases autoreactivity and susceptibility to autoimmune disease development.
      Title: Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.
    3. investigated H2-O, H2-M, and I-A(b)-CLIP expression patterns in B cell subsets during B cell development and activation
      Title: Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function.
    4. H2-O predominantly inhibits antigen presentation in early endosomal compartments. Thus, H2-O appears to skew peptide loading to late endosomal/lysosomal compartments. This may favor presentation of antigens taken up by the B cell receptor.
      Title: Downmodulation of antigen presentation by H2-O in B cell lines and primary B lymphocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility 2, O region alpha locus
    Names
    MHC class II antigen O region alpha locus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008206.2 → NP_032232.2  histocompatibility 2, O region alpha locus precursor

      See identical proteins and their annotated locations for NP_032232.2

      Status: VALIDATED

      Source sequence(s)
      AK020594, BC138996, CO795887
      Consensus CDS
      CCDS37577.1
      UniProtKB/TrEMBL
      B2RST7, Q9QWV1
      Related
      ENSMUSP00000025192.8, ENSMUST00000025192.8
      Conserved Domains (3) summary
      cd05767
      Location:112 → 205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:30 → 108
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:203 → 250
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34311353..34314286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160330.1 → XP_036016223.1  histocompatibility 2, O region alpha locus isoform X1

      UniProtKB/TrEMBL
      B2RST7
      Conserved Domains (2) summary
      pfam00993
      Location:1 → 78
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cd21004
      Location:81 → 175
      IgC1_MHC_II_alpha_HLA_DO; HLA class II histocompatibility antigen DO alpha; member of the C1-set of Ig superfamily (IgSF) domains
    Nucleotide Protein Strain
    Heading Accession and Version

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