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    Mterf1a mitochondrial transcription termination factor 1a [ Mus musculus (house mouse) ]

    Gene ID: 545725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mterf1aprovided by MGI
    Official Full Name
    mitochondrial transcription termination factor 1aprovided by MGI
    Primary source
    MGI:MGI:1918240
    See related
    Ensembl:ENSMUSG00000040429 AllianceGenome:MGI:1918240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mterf; Mterf1; mTERF1b; 4931431L11Rik; 9230106K09Rik
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA geometric change and termination of mitochondrial transcription. Located in mitochondrion. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 1.7), CNS E11.5 (RPKM 1.6) and 23 other tissues See more
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    Genomic context

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    See Mterf1a in Genome Data Viewer
    Location:
    5 A1; 5 2.26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3914576..3943933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3864565..3893933, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4742 Neighboring gene STARR-seq mESC enhancer starr_12318 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene STARR-seq mESC enhancer starr_12319 Neighboring gene STARR-seq mESC enhancer starr_12320 Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1296 Neighboring gene Rps4x retrotransposed pseudogene Neighboring gene STARR-seq mESC enhancer starr_12321 Neighboring gene predicted gene, 51438 Neighboring gene A kinase anchor protein 9 Neighboring gene Wdr46 retrotransposed pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Terzioglu M, et al. Cell Metab, 2013 Apr 2. PMID 23562081
    2. Cloning and characterization of mouse mTERF encoding a mitochondrial transcriptional termination factor. Li X, et al. Biochem Biophys Res Commun, 2005 Jan 14. PMID 15582606
    3. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. McNally RS, et al. J Biol Chem, 2011 Feb 11. PMID 21097510, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter.
      Title: MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA geometric change ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA geometric change ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA-templated transcription termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated transcription termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in termination of mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 1a, mitochondrial
    Names
    mitochondrial transcription termination factor 1
    mitochondrial transcription termination factor 1b
    transcription termination factor, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013023.2 → NP_001013041.2  transcription termination factor 1a, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001013041.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027653, AK049308
      Consensus CDS
      CCDS39003.1
      UniProtKB/Swiss-Prot
      Q63ZX5, Q8C7T1, Q8CHZ9
      Related
      ENSMUSP00000046017.5, ENSMUST00000044746.5
      Conserved Domains (1) summary
      pfam02536
      Location:58 → 371
      mTERF; mTERF

    2. NM_172135.2 → NP_742147.1  transcription termination factor 1a, mitochondrial precursor

      See identical proteins and their annotated locations for NP_742147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027653, CJ061450
      Consensus CDS
      CCDS39003.1
      UniProtKB/Swiss-Prot
      Q63ZX5, Q8C7T1, Q8CHZ9
      Conserved Domains (1) summary
      pfam02536
      Location:58 → 371
      mTERF; mTERF

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      3914576..3943933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320999.3 → XP_017176488.1  transcription termination factor 1a, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam02536
      Location:60 → 373
      mTERF

    2. XM_017321000.2 → XP_017176489.1  transcription termination factor 1a, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam02536
      Location:60 → 373
      mTERF

    RNA

    1. XR_003955677.2 RNA Sequence

    2. XR_004942541.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHZ9.1 GenPept UniProtKB/Swiss-Prot:Q8CHZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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