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    Rex2 reduced expression 2 [ Mus musculus (house mouse) ]

    Gene ID: 100043034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rex2provided by MGI
    Official Full Name
    reduced expression 2provided by MGI
    Primary source
    MGI:MGI:1328322
    See related
    Ensembl:ENSMUSG00000067919 AllianceGenome:MGI:1328322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm13138
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in blastocyst; early embryo; and limb. Orthologous to human ZNF616 (zinc finger protein 616). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Rex2 in Genome Data Viewer
    Location:
    4 E1; 4 78.42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (147058071..147145256)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (146973610..147060799)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene Neighboring gene predicted gene 13149 Neighboring gene STARR-seq mESC enhancer starr_12046 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146352913-146353213 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146354424-146354725 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146356350-146356650 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146358253-146358554 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146359517-146359818 Neighboring gene predicted gene, 46895 Neighboring gene STARR-positive B cell enhancer mm9_chr4:146416384-146416684 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene RIKEN cDNA 4933438K21 gene Neighboring gene predicted gene 13160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Faria TN, et al. Mol Cell Endocrinol, 1998 Aug 25. PMID 9806360
    2. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC76572

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reduced expression 2
    Names
    novel KRAB box domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177767.1 → NP_001171238.1  reduced expression 2

      Status: VALIDATED

      Source sequence(s)
      AL954334
      Consensus CDS
      CCDS51374.1
      UniProtKB/TrEMBL
      A2AWF2
      Related
      ENSMUSP00000075179.6, ENSMUST00000075775.6
      Conserved Domains (3) summary
      COG5048
      Location:277 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 67
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      147058071..147145256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253012.2 → XP_030108872.1  reduced expression 2 isoform X1

      UniProtKB/TrEMBL
      A2AWF2
      Conserved Domains (3) summary
      COG5048
      Location:277 → 666
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:27 → 67
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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