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    Nell1 NEL-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 338352, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nell1provided by MGI
    Official Full Name
    NEL-like 1provided by MGI
    Primary source
    MGI:MGI:2443902
    See related
    Ensembl:ENSMUSG00000055409 AllianceGenome:MGI:2443902
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    l7R6; B230343H07Rik
    Summary
    Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including basal columns; chondrocranium; tooth; tooth bud; and urinary system. Orthologous to human NELL1 (neural EGFL like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 7.7), cerebellum adult (RPKM 7.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Nell1 in Genome Data Viewer
    Location:
    7 B4; 7 31.79 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (49625098..50513037)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (49975350..50863289)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11738 Neighboring gene STARR-seq mESC enhancer starr_18916 Neighboring gene protein arginine N-methyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_18918 Neighboring gene STARR-seq mESC enhancer starr_18919 Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 5 Neighboring gene STARR-seq mESC enhancer starr_18921 Neighboring gene STARR-seq mESC enhancer starr_18922 Neighboring gene RIKEN cDNA 4933405O20 gene Neighboring gene NEL-like 1, opposite strand Neighboring gene predicted gene, 21032 Neighboring gene retinoblastoma binding protein 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (9)  1 citation
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables heparin binding  
    enables heparin binding  
    enables heparin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables protein kinase C binding  
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in negative regulation of osteoblast proliferation  
    involved_in negative regulation of osteoblast proliferation  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein catabolic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of ossification  
    involved_in positive regulation of ossification  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of osteoblast differentiation  
    involved_in regulation of osteoblast differentiation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in nuclear envelope  
    located_in nuclear envelope  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    protein kinase C-binding protein NELL1
    Names
    NEL-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037906.2NP_001032995.1  protein kinase C-binding protein NELL1 precursor

      See identical proteins and their annotated locations for NP_001032995.1

      Status: PROVISIONAL

      Source sequence(s)
      AC110036, AC115080, AC116694, AC116734, AC128699, AC161929, AC163402, AC171557
      Consensus CDS
      CCDS21309.1
      UniProtKB/Swiss-Prot
      Q2VWQ2
      UniProtKB/TrEMBL
      D3YWD8
      Related
      ENSMUSP00000080550.6, ENSMUST00000081872.13
      Conserved Domains (5) summary
      smart00179
      Location:549586
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:29213
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:596627
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:480515
      EGF_3; EGF domain
      cl17735
      Location:273331
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      49625098..50513037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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