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    Fam13b family with sequence similarity 13, member B [ Mus musculus (house mouse) ]

    Gene ID: 225358, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Fam13bprovided by MGI
    Official Full Name
    family with sequence similarity 13, member Bprovided by MGI
    Primary source
    MGI:MGI:2447834
    See related
    Ensembl:ENSMUSG00000036501 AllianceGenome:MGI:2447834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610024E20Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Orthologous to human FAM13B (family with sequence similarity 13 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.4), whole brain E14.5 (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam13b in Genome Data Viewer
    Location:
    18 B1; 18 18.69 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34573624..34656096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34440571..34523047, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene polycystic kidney disease 2-like 2 Neighboring gene SET translocation pseudogene Neighboring gene STARR-seq mESC enhancer starr_44201 Neighboring gene STARR-seq mESC enhancer starr_44203 Neighboring gene STARR-seq mESC enhancer starr_44204 Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling. Tchou G, et al. JACC Basic Transl Sci, 2023 Oct. PMID 38094680, Free PMC Article
    2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37079

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417763.1 → NP_001404692.1  protein FAM13B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115305

    2. NM_001417764.1 → NP_001404693.1  protein FAM13B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115305

    3. NM_001417765.1 → NP_001404694.1  protein FAM13B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115305

    4. NM_001417768.1 → NP_001404697.1  protein FAM13B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115305

    5. NM_001417769.1 → NP_001404698.1  protein FAM13B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC115305

    6. NM_001417770.1 → NP_001404699.1  protein FAM13B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC115305

    7. NM_001417771.1 → NP_001404700.1  protein FAM13B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC115305

    8. NM_001417772.1 → NP_001404701.1  protein FAM13B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC115305

    9. NM_001417773.1 → NP_001404702.1  protein FAM13B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC115305

    10. NM_001417775.1 → NP_001404704.1  protein FAM13B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC115305

    11. NM_001417776.1 → NP_001404705.1  protein FAM13B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC115305

    12. NM_146084.2 → NP_666196.1  protein FAM13B isoform 1

      See identical proteins and their annotated locations for NP_666196.1

      Status: VALIDATED

      Source sequence(s)
      AC115305
      Consensus CDS
      CCDS29128.1
      UniProtKB/Swiss-Prot
      Q8K2H3
      Related
      ENSMUSP00000038199.7, ENSMUST00000040506.8
      Conserved Domains (1) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34573624..34656096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525849.4 → XP_006525912.1  protein FAM13B isoform X1

      See identical proteins and their annotated locations for XP_006525912.1

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      pfam11719
      Location:566 → 645
      Drc1-Sld2; DNA replication and checkpoint protein

    2. XM_036161109.1 → XP_036017002.1  protein FAM13B isoform X16

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:733 → 772
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    3. XM_036161108.1 → XP_036017001.1  protein FAM13B isoform X14

      Conserved Domains (1) summary
      cl26235
      Location:555 → 594
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    4. XM_030250433.1 → XP_030106293.1  protein FAM13B isoform X12

    5. XM_006525854.2 → XP_006525917.1  protein FAM13B isoform X9

      See identical proteins and their annotated locations for XP_006525917.1

    6. XM_030250432.1 → XP_030106292.1  protein FAM13B isoform X12

    7. XM_036161106.1 → XP_036016999.1  protein FAM13B isoform X11

      Conserved Domains (1) summary
      cl26235
      Location:635 → 674
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    8. XM_006525853.2 → XP_006525916.1  protein FAM13B isoform X9

      See identical proteins and their annotated locations for XP_006525916.1

    9. XM_036161105.1 → XP_036016998.1  protein FAM13B isoform X7

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:765 → 804
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    10. XM_017317886.1 → XP_017173375.1  protein FAM13B isoform X5

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      pfam11719
      Location:544 → 621
      Drc1-Sld2; DNA replication and checkpoint protein

    11. XM_036161104.1 → XP_036016997.1  protein FAM13B isoform X6

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      cl26235
      Location:787 → 826
      RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins

    12. XM_006525852.3 → XP_006525915.1  protein FAM13B isoform X4

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      pfam11719
      Location:566 → 645
      Drc1-Sld2; DNA replication and checkpoint protein

    13. XM_006525858.2 → XP_006525921.1  protein FAM13B isoform X15

      See identical proteins and their annotated locations for XP_006525921.1

    14. XM_006525857.2 → XP_006525920.1  protein FAM13B isoform X15

      See identical proteins and their annotated locations for XP_006525920.1

    15. XM_006525855.4 → XP_006525918.1  protein FAM13B isoform X10

      Conserved Domains (2) summary
      cd04393
      Location:19 → 205
      RhoGAP_FAM13A1a; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound ...
      pfam11719
      Location:566 → 661
      Drc1-Sld2; DNA replication and checkpoint protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2H3.1 GenPept UniProtKB/Swiss-Prot:Q8K2H3

    Gene LinkOut

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