TC2N tandem C2 domains, nuclear [Homo sapiens (human)] - Gene

Summary

Official Symbol: TC2Nprovided by HGNC
Official Full Name: tandem C2 domains, nuclearprovided by HGNC
Primary source: HGNC:HGNC:19859
See related: Ensembl:ENSG00000165929 MIM:619305; AllianceGenome:HGNC:19859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C2CD1; TAC2N; Tac2-N; MTAC2D1; C14orf47
Summary: Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in gall bladder (RPKM 19.6), stomach (RPKM 15.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (91779746..91867536, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (86009200..86097026, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (92246090..92333880, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Title: TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/beta-Catenin Signaling Pathway.
Title: TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.
TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
Title: TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.
The TC2N attenuates p53 signaling pathway through inhibiting Cdk5-induced phosphorylation of p53 via inducing Cdk5 degradation or disrupting the interaction between Cdk5 and p53.
Title: TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer.
Study provided proof of principle to show that Tac2-N serves as a novel oncogene gene and plays an important role in the progression and metastasis of lung cancer.
Title: Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of tandem C2 domains, nuclear (TC2N) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-16622 (e-PCR)
- UniSTS:82386

SHGC-85001 (e-PCR)
- UniSTS:103382

RH120630 (e-PCR)
- UniSTS:132571

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tandem C2 domains nuclear protein

Names: C2 calcium-dependent domain containing 1; membrane targeting (tandem) C2 domain containing 1; tandem C2 protein in nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128595.3 → NP_001122067.2 tandem C2 domains nuclear protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AL121839

Consensus CDS

CCDS9897.1

UniProtKB/Swiss-Prot

Q8N9U0

Related

ENSP00000353802.5, ENST00000360594.9

Conserved Domains (2) summary

cd08684
Location:240 → 342

C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)

cd08692
Location:353 → 487

C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
NM_001128596.3 → NP_001122068.2 tandem C2 domains nuclear protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AL121839, AL590328

Consensus CDS

CCDS9897.1

UniProtKB/Swiss-Prot

Q8N9U0

Related

ENSP00000387882.2, ENST00000435962.7

Conserved Domains (2) summary

cd08684
Location:240 → 342

C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)

cd08692
Location:353 → 487

C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)
NM_001289134.2 → NP_001276063.2 tandem C2 domains nuclear protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL121839

Consensus CDS

CCDS73679.1

Related

ENSP00000451317.1, ENST00000556018.5

Conserved Domains (2) summary

cd08692
Location:289 → 423

C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

cl14603
Location:240 → 285

C2; C2 domain
NM_152332.6 → NP_689545.2 tandem C2 domains nuclear protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AL121839

Consensus CDS

CCDS9897.1

UniProtKB/Swiss-Prot

Q8N9U0

Related

ENSP00000343199.5, ENST00000340892.9

Conserved Domains (2) summary

cd08684
Location:240 → 342

C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)

cd08692
Location:353 → 487

C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)