PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3C2Gprovided by HGNC
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by HGNC
Primary source: HGNC:HGNC:8973
See related: Ensembl:ENSG00000139144 MIM:609001; AllianceGenome:HGNC:8973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI3K-C2GAMMA; PI3K-C2-gamma
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Biased expression in stomach (RPKM 3.1), skin (RPKM 2.0) and 7 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12p12.3

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (18242961..18726817)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (18118895..18602723)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (18414452..18801350)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking.
Title: Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking.
The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.
Title: The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.
Data indicate substituents of benzensulfonamide and pyrazine as phosphoinositide 3-kinase-C2gamma (PI3K-C2GAMMA) inhibitors.
Title: Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Observational study of gene-disease association. (HuGE Navigator)
Title: Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined.
Title: Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-na&#x000ef;ve patients with schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH103488 (e-PCR)
- UniSTS:97813

RH121621 (e-PCR)
- UniSTS:134194

D2S2813 (e-PCR)
- UniSTS:78163

SHGC-155945 (e-PCR)
- UniSTS:182626

RH121257 (e-PCR)
- UniSTS:138368

L29654 (e-PCR)
- UniSTS:13447

G62392 (e-PCR)
- UniSTS:139412

WI-12697 (e-PCR)
- UniSTS:76184

SHGC-106077 (e-PCR)
- UniSTS:169635

D12S2132 (e-PCR)
- UniSTS:16550

D12S1809 (e-PCR)
- UniSTS:36089

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-3-kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Names: PTDINS-3-kinase C2 gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide

NP_001275701.1

EC 2.7.1.137

EC 2.7.1.154

NP_001275703.1

EC 2.7.1.137

EC 2.7.1.154

NP_004561.3

EC 2.7.1.137

EC 2.7.1.154

XP_011518999.1

EC 2.7.1.137

EC 2.7.1.154

XP_011519003.1

EC 2.7.1.137

EC 2.7.1.154

XP_016874960.1

EC 2.7.1.137

EC 2.7.1.154

XP_016874962.1

EC 2.7.1.137

EC 2.7.1.154

XP_016874964.1

EC 2.7.1.137

EC 2.7.1.154

XP_016874967.1

EC 2.7.1.137

EC 2.7.1.154

XP_016874968.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284961.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284962.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284963.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284964.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284965.1

EC 2.7.1.137

EC 2.7.1.154

XP_047284966.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228258.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228259.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228260.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228261.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228262.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228263.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228264.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228265.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228266.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228267.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228268.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228269.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228270.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228271.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228272.1

EC 2.7.1.137

EC 2.7.1.154

XP_054228273.1

EC 2.7.1.137

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050635.2 RefSeqGene

Range

23559..410457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001288772.2 → NP_001275701.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1

See identical proteins and their annotated locations for NP_001275701.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC087236, AC087240, AC091815, AC092851, KF455618

Consensus CDS

CCDS73452.1

UniProtKB/Swiss-Prot

A1L3U0, F5H369, O75747

UniProtKB/TrEMBL

B7ZLY6

Related

ENSP00000445381.1, ENST00000538779.6

Conserved Domains (6) summary

cd06896
Location:1248 → 1348

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:520 → 678

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1370 → 1482

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:692 → 860

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05177
Location:866 → 1219

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl02484
Location:287 → 369

PI3K_rbd; PI3-kinase family, ras-binding domain
NM_001288774.2 → NP_001275703.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, which results in the use of an alternate start codon and a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC087236, AC087240, AC091815, AC092851, KF455618

UniProtKB/TrEMBL

B7ZLY6

Conserved Domains (6) summary

cd06896
Location:1026 → 1126

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:298 → 456

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:470 → 638

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05177
Location:644 → 997

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl02484
Location:65 → 147

PI3K_rbd; PI3-kinase family, ras-binding domain

cl14603
Location:1148 → 1260

C2; C2 domain
NM_004570.6 → NP_004561.3 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 3

See identical proteins and their annotated locations for NP_004561.3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AC087236, AC087240, AC091815, AC092851, KF455618

Consensus CDS

CCDS44839.1

UniProtKB/TrEMBL

B7ZLY6

Related

ENSP00000404845.1, ENST00000433979.6

Conserved Domains (6) summary

cd06896
Location:1207 → 1307

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd08381
Location:1329 → 1441

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:651 → 819

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05177
Location:825 → 1178

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl02484
Location:287 → 369

PI3K_rbd; PI3-kinase family, ras-binding domain

cl14603
Location:520 → 637

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

18242961..18726817

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429007.1 → XP_047284963.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X3
XM_017019471.2 → XP_016874960.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1

UniProtKB/TrEMBL

B7ZLY6
XM_047429008.1 → XP_047284964.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X4
XM_011520697.3 → XP_011518999.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X6

UniProtKB/TrEMBL

B7ZLY6

Conserved Domains (6) summary

cd06896
Location:1248 → 1348

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:520 → 678

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:692 → 860

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05177
Location:866 → 1219

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl02484
Location:287 → 369

PI3K_rbd; PI3-kinase family, ras-binding domain

cl14603
Location:1370 → 1436

C2; C2 domain
XM_047429005.1 → XP_047284961.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2

UniProtKB/Swiss-Prot

A1L3U0, F5H369, O75747

Related

ENSP00000501770.1, ENST00000676171.1
XM_047429009.1 → XP_047284965.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X5
XM_047429010.1 → XP_047284966.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X8
XM_017019475.2 → XP_016874964.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X7

UniProtKB/TrEMBL

B7ZLY6
XM_017019478.3 → XP_016874967.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X10

Conserved Domains (3) summary

cd04012
Location:520 → 678

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:692 → 834

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02484
Location:287 → 369

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_011520701.3 → XP_011519003.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X9

See identical proteins and their annotated locations for XP_011519003.1

Conserved Domains (3) summary

cd04012
Location:520 → 678

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:692 → 834

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02484
Location:287 → 369

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_017019473.3 → XP_016874962.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1

UniProtKB/TrEMBL

B7ZLY6
XM_047429006.1 → XP_047284962.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2

UniProtKB/Swiss-Prot

A1L3U0, F5H369, O75747

Related

ENSP00000501889.1, ENST00000675017.1
XM_017019479.2 → XP_016874968.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X11

Conserved Domains (4) summary

cd06896
Location:573 → 673

PX_PI3K_C2_gamma; The phosphoinositide binding Phox Homology Domain of the Gamma Isoform of Class II Phosphoinositide 3-Kinases

cd05177
Location:191 → 544

PI3Kc_C2_gamma; Catalytic domain of Class II Phosphoinositide 3-kinase gamma

cl00271
Location:17 → 185

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl14603
Location:695 → 761

C2; C2 domain

RNA

XR_931307.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

18118895..18602723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372284.1 → XP_054228259.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_054372290.1 → XP_054228265.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X4
XM_054372288.1 → XP_054228263.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X3
XM_054372285.1 → XP_054228260.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_054372283.1 → XP_054228258.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_054372293.1 → XP_054228268.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X13
XM_054372294.1 → XP_054228269.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X14
XM_054372289.1 → XP_054228264.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X12
XM_054372291.1 → XP_054228266.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X6
XM_054372292.1 → XP_054228267.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X7
XM_054372296.1 → XP_054228271.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X10
XM_054372295.1 → XP_054228270.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X9
XM_054372297.1 → XP_054228272.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X15
XM_054372286.1 → XP_054228261.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_054372287.1 → XP_054228262.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2
XM_054372298.1 → XP_054228273.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X11