Parpbp PARP1 binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parpbpprovided by MGI
Official Full Name: PARP1 binding proteinprovided by MGI
Primary source: MGI:MGI:1922567
See related: Ensembl:ENSMUSG00000035365 AllianceGenome:MGI:1922567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PARI; 4930547N16Rik
Summary: Predicted to enable DNA binding activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including endocrine gland; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human PARPBP (PARP1 binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in liver E14 (RPKM 4.2), liver E14.5 (RPKM 3.7) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (87927260..87982831, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88091398..88146969, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress
Title: PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.
Parpbp(4930547N16Rik) is strongly co-expressed with known cancer-associated genes.
Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pmch (e-PCR), detects polymorphism
- UniSTS:507162

AI503644 (e-PCR)
- UniSTS:164447

G73161 (e-PCR)
- UniSTS:231358

MARC_1391-1392:997375485:1 (e-PCR)
- UniSTS:231358

PMC199192P1 (e-PCR)
- UniSTS:271860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PCNA-interacting partner

Names: PARP-1 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029249.2 → NP_083525.1 PCNA-interacting partner

Status: VALIDATED

Source sequence(s)

AK030970, AK137160, BC070476

Consensus CDS

CCDS36022.1

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

UniProtKB/TrEMBL

A0A0R4J0G5

Related

ENSMUSP00000038375.10, ENSMUST00000048518.16

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

87927260..87982831 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514268.4 → XP_006514331.1 PCNA-interacting partner isoform X1

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II
XM_006514269.5 → XP_006514332.1 PCNA-interacting partner isoform X1

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II
XM_006514267.5 → XP_006514330.1 PCNA-interacting partner isoform X1

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II
XM_036156069.1 → XP_036011962.1 PCNA-interacting partner isoform X4

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4
XM_036156068.1 → XP_036011961.1 PCNA-interacting partner isoform X2

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

UniProtKB/TrEMBL

A0A0R4J0G5

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II
XM_011243597.3 → XP_011241899.1 PCNA-interacting partner isoform X3

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

Conserved Domains (1) summary

TIGR01075
Location:93 → 188

uvrD; DNA helicase II
XM_030245343.2 → XP_030101203.1 PCNA-interacting partner isoform X2

UniProtKB/Swiss-Prot

Q3UAQ9, Q3V278, Q6IRT3, Q8C0J4

UniProtKB/TrEMBL

A0A0R4J0G5

Conserved Domains (1) summary

TIGR01075
Location:174 → 269

uvrD; DNA helicase II
XM_017314131.2 → XP_017169620.1 PCNA-interacting partner isoform X5

UniProtKB/TrEMBL

E9Q6W8

Related

ENSMUSP00000128043.2, ENSMUST00000164803.2
XM_017314132.2 → XP_017169621.1 PCNA-interacting partner isoform X6

UniProtKB/TrEMBL

E9Q6W8