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    Lrguk leucine-rich repeats and guanylate kinase domain containing [ Mus musculus (house mouse) ]

    Gene ID: 74354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrgukprovided by MGI
    Official Full Name
    leucine-rich repeats and guanylate kinase domain containingprovided by MGI
    Primary source
    MGI:MGI:1921604
    See related
    Ensembl:ENSMUSG00000056215 AllianceGenome:MGI:1921604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921528H16Rik
    Summary
    Predicted to enable guanylate kinase activity. Involved in axoneme assembly and spermatogenesis. Located in acrosomal vesicle and manchette. Is expressed in olfactory epithelium. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.9), CNS E18 (RPKM 0.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrguk in Genome Data Viewer
    Location:
    6 A3.3; 6 14.75 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34006183..34110969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34029245..34134034)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 4 Neighboring gene predicted gene, 38785 Neighboring gene STARR-seq mESC enhancer starr_15525 Neighboring gene STARR-seq mESC enhancer starr_15527 Neighboring gene STARR-seq mESC enhancer starr_15528 Neighboring gene STARR-seq mESC enhancer starr_15529 Neighboring gene STARR-positive B cell enhancer ABC_E10372 Neighboring gene predicted gene 13853 Neighboring gene predicted gene, 38786 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34079401-34079510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34106119-34106374 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34126896-34127097 Neighboring gene solute carrier family 35, member B4 Neighboring gene predicted gene 13855

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. Okuda H, et al. FASEB J, 2017 Mar. PMID 28003339
    2. LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. Liu Y, et al. PLoS Genet, 2015 Mar. PMID 25781171, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axoneme assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat and guanylate kinase domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401521.1 → NP_001388450.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153817
      UniProtKB/TrEMBL
      A0A2I3BQA5
      Related
      ENSMUSP00000153993.2, ENSMUST00000228187.2

    2. NM_001401523.1 → NP_001388452.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153817
      UniProtKB/TrEMBL
      A0A8Q0LUS2
      Related
      ENSMUSP00000159470.1, ENSMUST00000240538.1

    3. NM_028886.2 → NP_083162.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

      See identical proteins and their annotated locations for NP_083162.1

      Status: VALIDATED

      Source sequence(s)
      AC153817
      Consensus CDS
      CCDS51745.1
      UniProtKB/Swiss-Prot
      Q9D5S7
      Related
      ENSMUSP00000065146.4, ENSMUST00000070189.10
      Conserved Domains (6) summary
      cd00071
      Location:416 → 537
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00116
      Location:150 → 339
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:131 → 150
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00625
      Location:417 → 599
      Guanylate_kin; Guanylate kinase
      pfam12799
      Location:260 → 300
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:282 → 339
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34006183..34110969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506713.5 → XP_006506776.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:678 → 1233
      PHA03247; large tegument protein UL36; Provisional
      cd00071
      Location:416 → 537
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      sd00033
      Location:131 → 150
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:132 → 333
      internalin_A; class 1 internalin InlA

    2. XM_011241496.3 → XP_011239798.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:132 → 649
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:14 → 230
      PRK12323; DNA polymerase III subunit gamma/tau
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5S7.1 GenPept UniProtKB/Swiss-Prot:Q9D5S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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