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    Spmip10 sperm microtubule inner protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 67343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spmip10provided by MGI
    Official Full Name
    sperm microtubule inner protein 10provided by MGI
    Primary source
    MGI:MGI:1914593
    See related
    Ensembl:ENSMUSG00000032900 AllianceGenome:MGI:1914593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tex43; Tseg7; 1700065I17Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal B tubule inner sheath and sperm flagellum. Orthologous to human SPMIP10 (sperm microtubule inner protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.5), CNS E11.5 (RPKM 11.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spmip10 in Genome Data Viewer
    Location:
    18 D3; 18 30.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56720690..56727855)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56587609..56594783)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene aldehyde dehydrogenase family 7, member A1 Neighboring gene STARR-seq mESC enhancer starr_44664 Neighboring gene microRNA 1258 Neighboring gene phosphorylated adaptor for RNA export Neighboring gene predicted gene, 50288 Neighboring gene STARR-seq mESC enhancer starr_44668 Neighboring gene STARR-positive B cell enhancer ABC_E5662 Neighboring gene predicted gene, 41738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2021 Aug 31. PMID 34446558, Free PMC Article
    2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm-associated microtubule inner protein 10
    Names
    testis expressed 43
    testis specific expressed protein 7
    testis-expressed protein 43
    testis-expressed sequence 43 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026099.3 → NP_080375.2  sperm-associated microtubule inner protein 10

      See identical proteins and their annotated locations for NP_080375.2

      Status: PROVISIONAL

      Source sequence(s)
      AK006893
      Consensus CDS
      CCDS29260.1
      UniProtKB/Swiss-Prot
      Q9D9I1
      UniProtKB/TrEMBL
      C9W8M4
      Related
      ENSMUSP00000038152.7, ENSMUST00000035640.13
      Conserved Domains (1) summary
      pfam14983
      Location:3 → 141
      DUF4513; Domain of unknown function (DUF4513)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      56720690..56727855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526175.5 → XP_006526238.1  sperm-associated microtubule inner protein 10 isoform X1

      Related
      ENSMUSP00000115084.2, ENSMUST00000147775.2
      Conserved Domains (1) summary
      pfam14983
      Location:3 → 99
      DUF4513; Domain of unknown function (DUF4513)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9I1.2 GenPept UniProtKB/Swiss-Prot:Q9D9I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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