Prss34 serine protease 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss34provided by MGI
Official Full Name: serine protease 34provided by MGI
Primary source: MGI:MGI:2681414
See related: Ensembl:ENSMUSG00000056399 AllianceGenome:MGI:2681414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcp11; mMcp-11; C130091P12
Summary: Enables heparin binding activity and serine-type peptidase activity. Predicted to be involved in proteolysis. Located in extracellular matrix and extracellular space. Is expressed in several structures, including dermis; immune system; lung; skeletal muscle; and testis. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 1.8), liver E18 (RPKM 1.4) and 10 other tissues See more
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25517368..25519142)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25298394..25300168)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

basophil tryptase mMCP-11 is a crucial effector molecule for the induction of immunoglobulin E-mediated chronic allergic inflammation.
Title: Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice.
basophil-derived mMCP-11 can induce microvascular leakage via prostaglandins in a mast cell-independent manner, and may contribute to the development of basophil-mediated inflammatory responses.
Title: Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.
basophils rather than mast cells are the major source of mMCP-11.
Title: Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Prss34 (e-PCR), detects polymorphism
- UniSTS:265740

NoName (e-PCR)
- UniSTS:487810

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mastin

Names: mast cell protease 11; protease, serine 34

NP_848459.1

EC 3.4.21.-

XP_011244801.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178372.2 → NP_848459.1 mastin precursor

See identical proteins and their annotated locations for NP_848459.1

Status: PROVISIONAL

Source sequence(s)

AY261775

Consensus CDS

CCDS28514.1

UniProtKB/TrEMBL

Q6RUT2, Q80UR4

Related

ENSMUSP00000045672.3, ENSMUST00000037453.5

Conserved Domains (2) summary

smart00020
Location:35 → 277

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:35 → 278

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25517368..25519142

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246499.1 → XP_011244801.1 mastin isoform X1

Conserved Domains (1) summary

cd00190
Location:9 → 198

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...