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    Zfp946 zinc finger protein 946 [ Mus musculus (house mouse) ]

    Gene ID: 74149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp946provided by MGI
    Official Full Name
    zinc finger protein 946provided by MGI
    Primary source
    MGI:MGI:1921399
    See related
    Ensembl:ENSMUSG00000071266 AllianceGenome:MGI:1921399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300003B13Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 6.0), CNS E14 (RPKM 5.5) and 23 other tissues See more
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    Genomic context

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    See Zfp946 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (22643102..22675670)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (22424182..22456689)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7072 Neighboring gene predicted gene, 53992 Neighboring gene zinc finger protein 944 Neighboring gene STARR-positive B cell enhancer ABC_E5576 Neighboring gene STARR-seq mESC enhancer starr_42030 Neighboring gene zinc finger protein 758 Neighboring gene STARR-seq mESC enhancer starr_42031 Neighboring gene STARR-positive B cell enhancer ABC_E5577 Neighboring gene STARR-seq mESC enhancer starr_42032 Neighboring gene STARR-seq mESC enhancer starr_42034 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene predicted gene, 30818

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 946

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331195.1 → NP_001318124.1  zinc finger protein 946 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC122270
      Conserved Domains (3) summary
      COG5048
      Location:262 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 74
      KRAB; KRAB box

    2. NM_001331196.1 → NP_001318125.1  zinc finger protein 946 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122270
      Conserved Domains (3) summary
      COG5048
      Location:262 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 74
      KRAB; KRAB box

    3. NM_001331197.1 → NP_001318126.1  zinc finger protein 946 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122270
      Consensus CDS
      CCDS50001.1
      UniProtKB/TrEMBL
      F6VWU8
      Related
      ENSMUSP00000132940.2, ENSMUST00000167740.2
      Conserved Domains (3) summary
      COG5048
      Location:240 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 52
      KRAB; KRAB box

    4. NM_001331198.1 → NP_001318127.1  zinc finger protein 946 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122270, AK004870, CJ086800
      Consensus CDS
      CCDS50001.1
      UniProtKB/TrEMBL
      F6VWU8
      Related
      ENSMUSP00000086141.7, ENSMUST00000088763.13
      Conserved Domains (3) summary
      COG5048
      Location:240 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 52
      KRAB; KRAB box

    5. NM_198003.3 → NP_932120.1  zinc finger protein 946 isoform b

      See identical proteins and their annotated locations for NP_932120.1

      Status: VALIDATED

      Source sequence(s)
      AC122270
      Consensus CDS
      CCDS50001.1
      UniProtKB/TrEMBL
      F6VWU8
      Related
      ENSMUSP00000113244.2, ENSMUST00000120222.8
      Conserved Domains (3) summary
      COG5048
      Location:240 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 52
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      22643102..22675670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160815.1 → XP_036016708.1  zinc finger protein 946 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:262 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 74
      KRAB; KRAB box

    2. XM_017317692.3 → XP_017173181.1  zinc finger protein 946 isoform X2

      UniProtKB/TrEMBL
      F6VWU8
      Conserved Domains (3) summary
      COG5048
      Location:240 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 52
      KRAB; KRAB box

    3. XM_030250109.2 → XP_030105969.1  zinc finger protein 946 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:262 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 74
      KRAB; KRAB box

    4. XM_017317693.3 → XP_017173182.1  zinc finger protein 946 isoform X2

      UniProtKB/TrEMBL
      F6VWU8
      Conserved Domains (3) summary
      COG5048
      Location:240 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 52
      KRAB; KRAB box

    5. XM_030250110.2 → XP_030105970.1  zinc finger protein 946 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:262 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:37 → 74
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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