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    Krt87 keratin 87 [ Mus musculus (house mouse) ]

    Gene ID: 406219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt87provided by MGI
    Official Full Name
    keratin 87provided by MGI
    Primary source
    MGI:MGI:3665486
    See related
    Ensembl:ENSMUSG00000047641 AllianceGenome:MGI:3665486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K83; K87; Krt83; Krt2-25
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 1.7), ovary adult (RPKM 0.8) and 11 other tissues See more
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    Genomic context

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    See Krt87 in Genome Data Viewer
    Location:
    15 F2; 15 56.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101329371..101336685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101431490..101438804, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35853 Neighboring gene predicted gene 671 Neighboring gene STARR-seq mESC enhancer starr_39796 Neighboring gene keratin 7 Neighboring gene keratin 88 Neighboring gene keratin 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. Jheon AH, et al. J Cell Sci, 2011 Mar 1. PMID 21285247, Free PMC Article
    2. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
    3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular 87
    Names
    keratin complex 2, basic, gene 25
    keratin, type II cuticular Hb3
    keratin-83
    type II hair keratin Hb3
    type-II keratin Kb23
    type-II keratin Kb25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003668.2 → NP_001003668.2  keratin, type II cuticular 87

      See identical proteins and their annotated locations for NP_001003668.2

      Status: VALIDATED

      Source sequence(s)
      AA755006, BC139321
      Consensus CDS
      CCDS27852.1
      UniProtKB/Swiss-Prot
      B2RTF5, Q6IMF0
      UniProtKB/TrEMBL
      Q61726
      Related
      ENSMUSP00000080613.4, ENSMUST00000081945.5
      Conserved Domains (3) summary
      pfam00038
      Location:110 → 421
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 107
      Keratin_2_head; Keratin type II head
      cl23720
      Location:320 → 388
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101329371..101336685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IMF0.2 GenPept UniProtKB/Swiss-Prot:Q6IMF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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