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    Asb2 ankyrin repeat and SOCS box-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 65256, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asb2provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 2provided by MGI
    Primary source
    MGI:MGI:1929743
    See related
    Ensembl:ENSMUSG00000021200 AllianceGenome:MGI:1929743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110008E15Rik
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Acts upstream of or within skeletal muscle cell differentiation. Located in Z disc. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart; and musculature. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 165.8), spleen adult (RPKM 62.0) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Asb2 in Genome Data Viewer
    Location:
    12 E; 12 52.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103287401..103322260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103321142..103356001, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene proline rich membrane anchor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7173 Neighboring gene family with sequence similarity 181, member A Neighboring gene predicted gene 29508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:104569739-104569961 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene DEAD box helicase 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 2
    Names
    ASB-2
    ankyrin repeat and SOCS box-containing protein 2
    ankyrin repeat-containing SOCS box protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374764.1NP_001361693.1  ankyrin repeat and SOCS box protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160131, AK083400
      Consensus CDS
      CCDS88394.1
      Related
      ENSMUSP00000117595.2, ENSMUST00000149431.2
      Conserved Domains (4) summary
      PHA02876
      Location:105421
      PHA02876; ankyrin repeat protein; Provisional
      cd03721
      Location:542586
      SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
      sd00045
      Location:189220
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:58109
      Ank_4; Ankyrin repeats (many copies)
    2. NM_023049.1NP_075536.1  ankyrin repeat and SOCS box protein 2 isoform 1

      See identical proteins and their annotated locations for NP_075536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC031161
      Consensus CDS
      CCDS26128.1
      UniProtKB/Swiss-Prot
      Q8K0L0, Q9CTH4, Q9WV73
      Related
      ENSMUSP00000021617.8, ENSMUST00000021617.14
      Conserved Domains (4) summary
      PHA03095
      Location:199480
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:112202
      Ank_2; Ankyrin repeats (3 copies)
      cl02533
      Location:590634
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103287401..103322260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)