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    Ism2 isthmin 2 [ Mus musculus (house mouse) ]

    Gene ID: 217738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ism2provided by MGI
    Official Full Name
    isthmin 2provided by MGI
    Primary source
    MGI:MGI:2685110
    See related
    Ensembl:ENSMUSG00000050671 AllianceGenome:MGI:2685110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm264; Thsd3
    Summary
    Is expressed in embryo. Orthologous to human ISM2 (isthmin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 2.0), subcutaneous fat pad adult (RPKM 1.1) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ism2 in Genome Data Viewer
    Location:
    12 D2; 12 41.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87325412..87346624, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87278638..87299850, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene AHA1, activator of heat shock protein ATPase 1 Neighboring gene predicted gene, 53736 Neighboring gene STARR-seq mESC enhancer starr_32874 Neighboring gene predicted gene, 51956 Neighboring gene STARR-seq mESC enhancer starr_32879 Neighboring gene serine palmitoyltransferase, long chain base subunit 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88729340-88729523 Neighboring gene predicted gene, 33444 Neighboring gene STARR-seq mESC enhancer starr_32884 Neighboring gene 60S ribosomal protein L21-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    isthmin-2
    Names
    isthmin 2 homolog
    thrombospondin, type I, domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290302.1 → NP_001277231.1  isthmin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151967, BQ032954, BU054611, CT030249
      Consensus CDS
      CCDS70410.1
      UniProtKB/TrEMBL
      D3Z6A3, F6YQQ5
      Related
      ENSMUSP00000117108.2, ENSMUST00000125733.8
      Conserved Domains (2) summary
      smart00209
      Location:252 → 292
      TSP1; Thrombospondin type 1 repeats
      cl02758
      Location:321 → 481
      AMOP; AMOP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      87325412..87346624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157339.1 → XP_036013232.1  isthmin-2 isoform X1

      Conserved Domains (2) summary
      smart00209
      Location:113 → 153
      TSP1; Thrombospondin type 1 repeats
      cl02758
      Location:182 → 342
      AMOP; AMOP domain

    RNA

    1. XR_003950040.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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