Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcns3provided by MGI
Official Full Name: potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3provided by MGI
Primary source: MGI:MGI:1098804
See related: Ensembl:ENSMUSG00000043673 AllianceGenome:MGI:1098804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 2.9), genital fat pad adult (RPKM 2.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 5.58 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (11140738..11201186, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (11090202..11151168, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
Title: Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Markers

UniSTS:236805 (e-PCR)
- UniSTS:236805

BB386162 (e-PCR)
- UniSTS:208780

D12Ertd137e (e-PCR), detects polymorphism
- UniSTS:167082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delayed-rectifier potassium channel regulatory subunit KCNS3; potassium voltage-gated channel subfamily S member 3

Names: delayed-rectifier potassium channel subunit Kv9.3; voltage-gated potassium channel subunit Kv9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168564.2 → NP_001162036.1 delayed-rectifier potassium channel regulatory subunit KCNS3

See identical proteins and their annotated locations for NP_001162036.1

Status: VALIDATED

Source sequence(s)

AC120406

Consensus CDS

CCDS25813.1

UniProtKB/Swiss-Prot

Q8BQZ8

Related

ENSMUSP00000129412.2, ENSMUST00000164495.9

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein
NM_001413254.1 → NP_001400183.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8
NM_001413255.1 → NP_001400184.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8
NM_001413256.1 → NP_001400185.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8

Related

ENSMUSP00000152026.2, ENSMUST00000217974.2
NM_001413257.1 → NP_001400186.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8
NM_001413258.1 → NP_001400187.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8
NM_001413259.1 → NP_001400188.1 delayed-rectifier potassium channel regulatory subunit KCNS3

Status: VALIDATED

Source sequence(s)

AC120406

UniProtKB/Swiss-Prot

Q8BQZ8
NM_173417.4 → NP_775593.1 delayed-rectifier potassium channel regulatory subunit KCNS3

See identical proteins and their annotated locations for NP_775593.1

Status: VALIDATED

Source sequence(s)

AC120406

Consensus CDS

CCDS25813.1

UniProtKB/Swiss-Prot

Q8BQZ8

Related

ENSMUSP00000060706.2, ENSMUST00000055673.2

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

11140738..11201186 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243867.1 → XP_011242169.1 potassium voltage-gated channel subfamily S member 3 isoform X2

See identical proteins and their annotated locations for XP_011242169.1

Conserved Domains (2) summary

cl38908
Location:4 → 40

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:102 → 335

Ion_trans; Ion transport protein
XM_011243866.3 → XP_011242168.1 potassium voltage-gated channel subfamily S member 3 isoform X1

See identical proteins and their annotated locations for XP_011242168.1

UniProtKB/Swiss-Prot

Q8BQZ8

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein
XM_006515080.4 → XP_006515143.1 potassium voltage-gated channel subfamily S member 3 isoform X1

See identical proteins and their annotated locations for XP_006515143.1

UniProtKB/Swiss-Prot

Q8BQZ8

Conserved Domains (2) summary

cd18428
Location:15 → 122

BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)

pfam00520
Location:184 → 417

Ion_trans; Ion transport protein
XM_006515082.4 → XP_006515145.1 potassium voltage-gated channel subfamily S member 3 isoform X2

See identical proteins and their annotated locations for XP_006515145.1

Conserved Domains (2) summary

cl38908
Location:4 → 40

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:102 → 335

Ion_trans; Ion transport protein