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    Lyset lysosomal enzyme trafficking factor [ Mus musculus (house mouse) ]

    Gene ID: 320351, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lysetprovided by MGI
    Official Full Name
    lysosomal enzyme trafficking factorprovided by MGI
    Primary source
    MGI:MGI:2443862
    See related
    Ensembl:ENSMUSG00000046675 AllianceGenome:MGI:2443862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem251; D230037D09Rik
    Summary
    Predicted to be involved in lysosomal transport; lysosome organization; and regulation of vesicle-mediated transport. Predicted to be located in Golgi cisterna and Golgi membrane. Orthologous to human LYSET (lysosomal enzyme trafficking factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 7.2), placenta adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lyset in Genome Data Viewer
    Location:
    12 E; 12 52.15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102709978..102714551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102743719..102745406)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30296 Neighboring gene STARR-seq mESC enhancer starr_33116 Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene STARR-positive B cell enhancer ABC_E9390 Neighboring gene predicted gene 20604 Neighboring gene modulator of apoptosis 1 Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_33119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in lysosomal transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    lysosomal enzyme trafficking factor
    Names
    UPF0694 transmembrane protein C14orf109 homolog
    transmembrane protein 251

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324515.3NP_001311444.2  lysosomal enzyme trafficking factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132315
      UniProtKB/TrEMBL
      Q3UZD1
      Conserved Domains (1) summary
      pfam15190
      Location:2129
      TMEM251; Transmembrane protein 251
    2. NM_177140.5NP_796114.1  lysosomal enzyme trafficking factor isoform 1

      See identical proteins and their annotated locations for NP_796114.1

      Status: VALIDATED

      Source sequence(s)
      AC132315
      Consensus CDS
      CCDS49146.1
      UniProtKB/Swiss-Prot
      Q8BH26
      UniProtKB/TrEMBL
      Q3UZD1
      Related
      ENSMUSP00000054611.7, ENSMUST00000057416.8
      Conserved Domains (1) summary
      pfam15190
      Location:34161
      DUF4583; Domain of unknown function (DUF4583)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102709978..102714551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)