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    Chga chromogranin A [ Mus musculus (house mouse) ]

    Gene ID: 12652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chgaprovided by MGI
    Official Full Name
    chromogranin Aprovided by MGI
    Primary source
    MGI:MGI:88394
    See related
    Ensembl:ENSMUSG00000021194 AllianceGenome:MGI:88394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cgA; ChrA
    Summary
    This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in adrenal adult (RPKM 976.1) and stomach adult (RPKM 145.4) See more
    Orthologs
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    Genomic context

    See Chga in Genome Data Viewer
    Location:
    12 E; 12 51.66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102521200..102531286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102554941..102565027)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7170 Neighboring gene STARR-positive B cell enhancer ABC_E3066 Neighboring gene STARR-positive B cell enhancer ABC_E9150 Neighboring gene predicted gene, 30198 Neighboring gene STARR-positive B cell enhancer ABC_E7171 Neighboring gene STARR-seq mESC enhancer starr_33098 Neighboring gene golgin A5 Neighboring gene STARR-seq mESC enhancer starr_33099 Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene VISTA enhancer mm491 Neighboring gene microRNA 1936 Neighboring gene STARR-seq mESC enhancer starr_33110 Neighboring gene STARR-seq mESC enhancer starr_33116 Neighboring gene predicted gene, 30296

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mast cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of catecholamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of catecholamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of catecholamine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dense core granule biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in chromaffin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromaffin granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromaffin granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007693.2NP_031719.1  chromogranin-A preproprotein

      See identical proteins and their annotated locations for NP_031719.1

      Status: REVIEWED

      Source sequence(s)
      BY250052, M64278
      Consensus CDS
      CCDS26120.1
      UniProtKB/Swiss-Prot
      P26339
      Related
      ENSMUSP00000021610.6, ENSMUST00000021610.7
      Conserved Domains (1) summary
      pfam01271
      Location:25463
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102521200..102531286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)