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    Magea9 MAGE family member A9 [ Mus musculus (house mouse) ]

    Gene ID: 70696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magea9provided by MGI
    Official Full Name
    MAGE family member A9provided by MGI
    Primary source
    MGI:MGI:1917946
    See related
    Ensembl:ENSMUSG00000031179 AllianceGenome:MGI:1917946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830417A13Rik
    Summary
    Predicted to enable caspase binding activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 37.7) See more
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    Genomic context

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    See Magea9 in Genome Data Viewer
    Location:
    X A7.1; X 34.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (63217154..63222385)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (64173548..64178779)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene prothymosin alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_47267 Neighboring gene STARR-seq mESC enhancer starr_47268 Neighboring gene predicted gene 6760 Neighboring gene SLIT and NTRK-like family, member 4 Neighboring gene DMRT-like family C1c2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables caspase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC70696

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027512.2 → NP_081788.2  uncharacterized protein LOC70696

      See identical proteins and their annotated locations for NP_081788.2

      Status: VALIDATED

      Source sequence(s)
      AK049539, AL807820
      Consensus CDS
      CCDS30166.1
      UniProtKB/TrEMBL
      Q6NV89, Q8BQJ2
      Related
      ENSMUSP00000033522.9, ENSMUST00000033522.15
      Conserved Domains (2) summary
      pfam01454
      Location:103 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 95
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      63217154..63222385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251498.1 → XP_030107358.1  uncharacterized protein LOC70696 isoform X1

      UniProtKB/TrEMBL
      Q6NV89, Q8BQJ2
      Conserved Domains (2) summary
      pfam01454
      Location:103 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 95
      MAGE_N; Melanoma associated antigen family N terminal

    2. XM_030251497.1 → XP_030107357.1  uncharacterized protein LOC70696 isoform X1

      UniProtKB/TrEMBL
      Q6NV89, Q8BQJ2
      Conserved Domains (2) summary
      pfam01454
      Location:103 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 95
      MAGE_N; Melanoma associated antigen family N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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