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    Trappc4 trafficking protein particle complex 4 [ Mus musculus (house mouse) ]

    Gene ID: 60409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trappc4provided by MGI
    Official Full Name
    trafficking protein particle complex 4provided by MGI
    Primary source
    MGI:MGI:1926211
    See related
    Ensembl:ENSMUSG00000032112 AllianceGenome:MGI:1926211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sbd; Sbdn; TRS23; PTD009; Sdcbp2; HSPC172; 1500017G03Rik
    Summary
    Involved in dendrite development. Located in Golgi stack; dendrite; and synaptic vesicle. Part of TRAPP complex. Is active in postsynaptic density membrane and presynaptic active zone. Is expressed in central nervous system; ganglia; olfactory epithelium; thymus primordium; and tooth. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 46.5), CNS E14 (RPKM 40.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trappc4 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44315057..44318629, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44403755..44407548, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5063 Neighboring gene predicted gene, 26306 Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085 Neighboring gene STARR-positive B cell enhancer ABC_E2291 Neighboring gene ribosomal protein S25 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene STARR-seq mESC enhancer starr_23968 Neighboring gene forkhead box R1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. Kong X, et al. J Natl Cancer Inst, 2013 Nov 20. PMID 24104608, Free PMC Article
    2. Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Wang X, et al. Cells, 2020 May 4. PMID 32375403, Free PMC Article
    3. Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines. Ethell IM, et al. J Cell Biol, 2000 Oct 2. PMID 11018053, Free PMC Article
    4. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922
    5. Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Hu M, et al. Int J Biol Sci, 2023. PMID 37416774, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
      Title: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
    2. Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC.
      Title: Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPPII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 4
    Names
    TRS23 homolog
    synbindin
    syndecan binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417827.1 → NP_001404756.1  trafficking protein particle complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122428
      Related
      ENSMUST00000213747.2

    2. NM_021789.3 → NP_068561.1  trafficking protein particle complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_068561.1

      Status: VALIDATED

      Source sequence(s)
      AC122428
      Consensus CDS
      CCDS23109.1
      UniProtKB/Swiss-Prot
      Q9DB31, Q9ES56
      UniProtKB/TrEMBL
      Q3V493, Q544R8
      Related
      ENSMUSP00000034623.7, ENSMUST00000034623.8
      Conserved Domains (1) summary
      cd14856
      Location:4 → 205
      TRAPPC4_synbindin; Trafficking protein particle complex subunit 4

    RNA

    1. NR_184635.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122428

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44315057..44318629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES56.1 GenPept UniProtKB/Swiss-Prot:Q9ES56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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