Krt9 keratin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt9provided by MGI
Official Full Name: keratin 9provided by MGI
Primary source: MGI:MGI:96696
See related: Ensembl:ENSMUSG00000051617 AllianceGenome:MGI:96696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K9; EPPK; Krt1-9
Summary: Predicted to enable structural molecule activity. Involved in spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in keratin filament. Is expressed in several structures, including alimentary system; gonad; hemolymphoid system gland; metanephros; and respiratory system. Human ortholog(s) of this gene implicated in epidermolytic palmoplantar keratoderma 1. Orthologous to human KRT9 (keratin 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 2.3), cortex adult (RPKM 1.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.43 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100077607..100084072, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100186781..100193246, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data demonstrate that complete ablation of K9 is not tolerable in vivo and that K9 is required for terminal differentiation and maintaining the mechanical integrity of palmoplantar epidermis.
Title: Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis.
Intron 6 influences the transcriptional efficiency of the keratin 9 (K9, Krt1-9) gene by decreasing production of wild-type K9 and changing the expression of K9 proteins.
Title: Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 9

Names: CK-9; cytokeratin-9; keratin complex 1, acidic, gene 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.