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    SIRPD signal regulatory protein delta [ Homo sapiens (human) ]

    Gene ID: 128646, updated on 27-Nov-2024

    Summary

    Official Symbol
    SIRPDprovided by HGNC
    Official Full Name
    signal regulatory protein deltaprovided by HGNC
    Primary source
    HGNC:HGNC:16248
    See related
    Ensembl:ENSG00000125900 AllianceGenome:HGNC:16248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPNS1L2; dJ576H24.4
    Summary
    Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 26.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SIRPD in Genome Data Viewer
    Location:
    20p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1534251..1557705, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1583429..1606887, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1514897..1538351, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1501740-1502939 Neighboring gene RNA, U6 small nuclear 917, pseudogene Neighboring gene uncharacterized LOC107985409 Neighboring gene signal regulatory protein beta 1 Neighboring gene TVP23B pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    signal-regulatory protein delta
    Names
    SIRP-delta
    protein tyrosine phosphatase, non-receptor type substrate 1-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410802.1NP_001397731.1  signal-regulatory protein delta isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL049634
      Consensus CDS
      CCDS93001.1
      UniProtKB/TrEMBL
      Q5TFQ5
      Related
      ENSP00000371034.1, ENST00000381621.5
    2. NM_178460.3NP_848555.2  signal-regulatory protein delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_848555.2

      Status: VALIDATED

      Source sequence(s)
      AL049634, BC033502, DA466740
      Consensus CDS
      CCDS13018.1
      UniProtKB/Swiss-Prot
      B3KS88, Q5TFQ6, Q9H106
      Related
      ENSP00000371036.3, ENST00000381623.4
      Conserved Domains (2) summary
      smart00410
      Location:38118
      IG_like; Immunoglobulin like
      pfam07686
      Location:34140
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      1534251..1557705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439883.1XP_047295839.1  signal-regulatory protein delta isoform X1

    2. XM_047439887.1XP_047295843.1  signal-regulatory protein delta isoform X4

    3. XM_047439886.1XP_047295842.1  signal-regulatory protein delta isoform X3

    4. XM_047439885.1XP_047295841.1  signal-regulatory protein delta isoform X2

    5. XM_047439888.1XP_047295844.1  signal-regulatory protein delta isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      1583429..1606887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322961.1XP_054178936.1  signal-regulatory protein delta isoform X1

    2. XM_054322963.1XP_054178938.1  signal-regulatory protein delta isoform X3

    3. XM_054322962.1XP_054178937.1  signal-regulatory protein delta isoform X2

    4. XM_054322964.1XP_054178939.1  signal-regulatory protein delta isoform X5