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    ZNF823 zinc finger protein 823 [ Homo sapiens (human) ]

    Gene ID: 55552, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF823provided by HGNC
    Official Full Name
    zinc finger protein 823provided by HGNC
    Primary source
    HGNC:HGNC:30936
    See related
    Ensembl:ENSG00000197933 AllianceGenome:HGNC:30936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSZFP36
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 2.9), colon (RPKM 2.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF823 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11721265..11738946, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11849432..11867152, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11832080..11849761, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11785131-11785688 Neighboring gene zinc finger protein 833, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr19.1989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14032 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11849745-11849939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10130 Neighboring gene uncharacterized LOC124904639 Neighboring gene zinc finger protein 441 Neighboring gene MPRA-validated peak3359 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11908593-11909104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14035 Neighboring gene zinc finger protein 491

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
    2. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    3. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 823
    Names
    ZFP 36 for a zinc finger protein
    zinc finger protein ZFP-36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080493.4 → NP_001073962.1  zinc finger protein 823 isoform 1

      See identical proteins and their annotated locations for NP_001073962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC052597, DA519419
      Consensus CDS
      CCDS45981.1
      UniProtKB/Swiss-Prot
      A0PJL4, B7Z8D4, P16415, Q6P4A9
      Related
      ENSP00000340683.5, ENST00000341191.11
      Conserved Domains (5) summary
      smart00349
      Location:4 → 40
      KRAB; krueppel associated box
      COG5048
      Location:109 → 546
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 40
      KRAB; KRAB box
      pfam13465
      Location:513 → 537
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001297610.2 → NP_001284539.1  zinc finger protein 823 isoform 3

      See identical proteins and their annotated locations for NP_001284539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1
      Source sequence(s)
      AK303213, BC052597
      UniProtKB/Swiss-Prot
      P16415
      Conserved Domains (3) summary
      COG5048
      Location:9 → 392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 355
      zf-H2C2_2; Zinc-finger double domain

    3. NM_017507.2 → NP_059977.1  zinc finger protein 823 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK308189, BC052597, DA519419
      UniProtKB/Swiss-Prot
      P16415
      Related
      ENSP00000410654.1, ENST00000431998.1
      Conserved Domains (3) summary
      COG5048
      Location:65 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:457 → 477
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:469 → 493
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11721265..11738946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026942.2 → XP_016882431.1  zinc finger protein 823 isoform X2

      UniProtKB/Swiss-Prot
      P16415
      Conserved Domains (3) summary
      COG5048
      Location:9 → 392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 355
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017026941.2 → XP_016882430.1  zinc finger protein 823 isoform X2

      UniProtKB/Swiss-Prot
      P16415
      Conserved Domains (3) summary
      COG5048
      Location:9 → 392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 339
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 355
      zf-H2C2_2; Zinc-finger double domain

    3. XM_024451586.2 → XP_024307354.1  zinc finger protein 823 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:77 → 514
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:510 → 534
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11849432..11867152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321398.1 → XP_054177373.1  zinc finger protein 823 isoform X2

    2. XM_054321397.1 → XP_054177372.1  zinc finger protein 823 isoform X2

    3. XM_054321396.1 → XP_054177371.1  zinc finger protein 823 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16415.2 GenPept UniProtKB/Swiss-Prot:P16415

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