EEF2K eukaryotic elongation factor 2 kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: EEF2Kprovided by HGNC
Official Full Name: eukaryotic elongation factor 2 kinaseprovided by HGNC
Primary source: HGNC:HGNC:24615
See related: Ensembl:ENSG00000103319 MIM:606968; AllianceGenome:HGNC:24615
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: eEF-2K; CaMKIII; HSU93850
Summary: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p12.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (22206278..22288738)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (21928475..22010936, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (22217599..22300059)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.
Title: Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.
Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
Title: Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.
Title: Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.
eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.
Title: eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.
Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
Title: Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.
Title: Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
Title: Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
Title: eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH15649 (e-PCR)
- UniSTS:14352

SHGC-6052 (e-PCR)
- UniSTS:49747

RH70484 (e-PCR)
- UniSTS:20070

D1S1423 (e-PCR)
- UniSTS:149619

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-141982 (e-PCR)
- UniSTS:171173

WI-11344 (e-PCR)
- UniSTS:693

D16S2643 (e-PCR)
- UniSTS:152250

EEF2K_8025 (e-PCR)
- UniSTS:467665

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables elongation factor-2 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables elongation factor-2 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables translation factor activity, RNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to anoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in myosin II filament disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to prolactin	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic elongation factor 2 kinase

Names: alternative protein EEF2K; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase

NP_037434.2

EC 2.7.11.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013302.5 → NP_037434.2 eukaryotic elongation factor 2 kinase

Status: REVIEWED

Source sequence(s)

AC009034

Consensus CDS

CCDS10604.1

UniProtKB/Swiss-Prot

O00418, Q8N588

UniProtKB/TrEMBL

A0AAG2TFE4

Related

ENSP00000263026.5, ENST00000263026.10

Conserved Domains (3) summary

COG0790
Location:533 → 713

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:547 → 576

SLR; SLR repeat [structural motif]

cd16967
Location:103 → 318

Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase