Il13ra2 interleukin 13 receptor, alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il13ra2provided by MGI
Official Full Name: interleukin 13 receptor, alpha 2provided by MGI
Primary source: MGI:MGI:1277954
See related: Ensembl:ENSMUSG00000031289 AllianceGenome:MGI:1277954
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD213a2; IL-13R-alpha-2
Summary: This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Biased expression in bladder adult (RPKM 1.3), frontal lobe adult (RPKM 0.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F2; X 68.46 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (146166474..146214982, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (147383478..147429192, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
Title: Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
Title: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis.
Title: Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis.
Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterusdagger.
Title: Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†.
Unique IL-13Ralpha2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination.
Title: Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination.
Study in Il13ra2 knockout and wild type mice exposed to dextran sodium sulfate to induce inflammatory bowel disease (IBD) suggest that Il13ra2 on epithelial cells contributes to IBD pathology by negatively influencing goblet cell recovery, goblet cell function and epithelial restoration after injury.
Title: Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease.
Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis.
Title: Detecting Chronic Post-Traumatic Osteomyelitis of Mouse Tibia via an IL-13Rα2 Targeted Metallofullerene Magnetic Resonance Imaging Probe.
Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway.
Title: IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.
overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis.
Title: Modulation of pulmonary fibrosis by IL-13Rα2.
data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation
Title: IL-13 receptor α2 contributes to development of experimental allergic asthma.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il13ra2 (e-PCR), detects polymorphism
- UniSTS:143538

Il13ra2 (e-PCR), detects polymorphism
- UniSTS:143539

Il13ra2 (e-PCR), detects polymorphism
- UniSTS:256477

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306059.1 → NP_001292988.1 interleukin-13 receptor subunit alpha-2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001292988.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL662932, AL807780, BX005200

UniProtKB/Swiss-Prot

O88786

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
NM_008356.4 → NP_032382.1 interleukin-13 receptor subunit alpha-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032382.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL662932, AL807780, BX005200

Consensus CDS

CCDS30460.1

UniProtKB/Swiss-Prot

A3F812, O88786, Q3V2V5

Related

ENSMUSP00000033646.3, ENSMUST00000033646.9

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

146166474..146214982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528707.4 → XP_006528770.1 interleukin-13 receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_006528770.1

UniProtKB/Swiss-Prot

A3F812, O88786, Q3V2V5

Related

ENSMUSP00000108446.2, ENSMUST00000112827.2

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_030251234.2 → XP_030107094.1 interleukin-13 receptor subunit alpha-2 isoform X2

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_017318395.2 → XP_017173884.1 interleukin-13 receptor subunit alpha-2 isoform X2

UniProtKB/Swiss-Prot

O88786

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_036161826.1 → XP_036017719.1 interleukin-13 receptor subunit alpha-2 isoform X1

UniProtKB/Swiss-Prot

A3F812, O88786, Q3V2V5

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_006528708.4 → XP_006528771.1 interleukin-13 receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_006528771.1

UniProtKB/Swiss-Prot

A3F812, O88786, Q3V2V5

Conserved Domains (1) summary

pfam09240
Location:136 → 229

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding