Wdr83 WD repeat domain containing 83 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr83provided by MGI
Official Full Name: WD repeat domain containing 83provided by MGI
Primary source: MGI:MGI:1915086
See related: Ensembl:ENSMUSG00000005150 AllianceGenome:MGI:1915086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Morg1; 1500041N16Rik
Summary: Acts upstream of or within several processes, including neural tube closure; placenta blood vessel development; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; decidua; extraembryonic component; islets of Langerhans; and renal proximal tubule. Orthologous to human WDR83 (WD repeat domain 83). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.1), CNS E14 (RPKM 24.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.55 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85801664..85807375, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (85075035..85080746, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy.
Title: WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy.
Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development.
Title: Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development.
MORG1 heterozygosity protects against histological renal damage and shows anti-inflammatory effects in a murine endotoxemia model.
Title: MORG1(+/-) mice are protected from histological renal damage and inflammation in a murine model of endotoxemia.
High MORG1 expression is associated with diabetic nephropathy.
Title: Heterozygosity of mitogen-activated protein kinase organizer 1 ameliorates diabetic nephropathy and suppresses epithelial-to-mesenchymal transition-like changes in db/db mice.
heterozygous deficiency protects against kidney injury induced by systemic hypoxia
Title: Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury.
this study shows for the first time in various renal cells that ANG II modulates Morg1 expression and HIF-1alpha transcriptional activity via cell type-specific mechanisms, demonstrating a novel mechanism by which ANG II may contribute to renal disease.
Title: Angiotensin II differentially regulates Morg1 expression in kidney cells.
The major finding of this study is that Morg1+/- mice are partially protected from cerebral ischemia and reperfusion injury in comparison to the WT (Morg1+/+) animals
Title: Morg1(+/-) heterozygous mice are protected from experimentally induced focal cerebral ischemia.
Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion
Title: Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_7999-8000:996688236:1 (e-PCR)
- UniSTS:269875

NoName (e-PCR)
- UniSTS:225076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA splicing, via transesterification reactions	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat domain-containing protein 83

Names: MAPK cascade scaffold protein; MAPK organizer 1; mitogen-activated protein kinase organizer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026399.2 → NP_080675.2 WD repeat domain-containing protein 83

See identical proteins and their annotated locations for NP_080675.2

Status: VALIDATED

Source sequence(s)

AY365434

Consensus CDS

CCDS22493.1

UniProtKB/Swiss-Prot

Q505C2, Q8VEB7, Q99JX9, Q9D235, Q9DAJ4

Related

ENSMUSP00000091048.6, ENSMUST00000093357.12

Conserved Domains (2) summary

cd00200
Location:19 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:30 → 65

7WD40; WD40 repeat [structural motif]