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    Scrg1 scrapie responsive gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 20284, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Scrg1provided by MGI
    Official Full Name
    scrapie responsive gene 1provided by MGI
    Primary source
    MGI:MGI:1328308
    See related
    Ensembl:ENSMUSG00000031610 AllianceGenome:MGI:1328308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in mesenchymal stem cell proliferation. Located in Golgi apparatus and neuron projection terminus. Is expressed in several structures, including central nervous system; cranium; foot bone; lung; and sternum. Orthologous to human SCRG1 (stimulator of chondrogenesis 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 7.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scrg1 in Genome Data Viewer
    Location:
    8 B2; 8 29.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57909093..57932441)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57455882..57479360)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21526 Neighboring gene predicted gene, 34099 Neighboring gene mannosidase 2, alpha 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21527 Neighboring gene RIKEN cDNA 2500002B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E1755 Neighboring gene STARR-seq mESC enhancer starr_21528 Neighboring gene sin3 associated polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Scrg1 is induced in TSE and brain injuries, and associated with autophagy. Dron M, et al. Eur J Neurosci, 2005 Jul. PMID 16029203
    2. Characterization of the human analogue of a Scrapie-responsive gene. Dron M, et al. J Biol Chem, 1998 Jul 17. PMID 9660755
    3. Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Durkin ME, et al. Gene, 2002 Apr 17. PMID 12034501
    4. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron M, et al. Genomics, 2000 Nov 15. PMID 11087671
    5. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, et al. J Biol Chem, 1998 Mar 27. PMID 9516475

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein.
      Title: Scrg1 is induced in TSE and brain injuries, and associated with autophagy.
    2. Scrg1 is associated with the secretory pathway of neuronal cells.
      Title: Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mesenchymal stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scrapie-responsive protein 1
    Names
    scRG-1
    scrapie responsive protein one
    scrapie-responsive gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424875.1 → NP_001411804.1  scrapie-responsive protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC128700, AC130841
      UniProtKB/Swiss-Prot
      O88745
      UniProtKB/TrEMBL
      Q543T5

    2. NM_009136.4 → NP_033162.1  scrapie-responsive protein 1 precursor

      See identical proteins and their annotated locations for NP_033162.1

      Status: VALIDATED

      Source sequence(s)
      AC128700, AC130841
      Consensus CDS
      CCDS40342.1
      UniProtKB/Swiss-Prot
      O88745
      UniProtKB/TrEMBL
      Q543T5
      Related
      ENSMUSP00000034023.4, ENSMUST00000034023.4
      Conserved Domains (1) summary
      pfam15224
      Location:22 → 97
      SCRG1; Scrapie-responsive protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      57909093..57932441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88745.1 GenPept UniProtKB/Swiss-Prot:O88745

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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