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    Septin1 septin 1 [ Mus musculus (house mouse) ]

    Gene ID: 54204, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Septin1provided by MGI
    Official Full Name
    septin 1provided by MGI
    Primary source
    MGI:MGI:1858916
    See related
    Ensembl:ENSMUSG00000000486 AllianceGenome:MGI:1858916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Diff6; Sept1; Pnutl3
    Summary
    Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Acts upstream of or within meiotic metaphase chromosome alignment and spindle assembly involved in female meiosis. Located in meiotic spindle and midbody. Is expressed in brain; cochlea; and thymus primordium. Orthologous to human SEPTIN1 (septin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 117.3), spleen adult (RPKM 47.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Septin1 in Genome Data Viewer
    Location:
    7 F3; 7 69.39 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126811881..126832157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127212709..127232985, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Tooley AJ, et al. Nat Cell Biol, 2009 Jan. PMID 19043408, Free PMC Article
    2. Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Nottenburg C, et al. Gene, 1990 Nov 15. PMID 2174398
    3. Septin1 is required for spindle assembly and chromosome congression in mouse oocytes. Zhu J, et al. Dev Dyn, 2011 Oct. PMID 21932310
    4. Biochemical and morphological characterization of SEPT1 in mouse brain. Ito H, et al. Med Mol Morphol, 2020 Dec. PMID 32146512
    5. Localization of septin proteins in the mouse cochlea. Yoshida A, et al. Hear Res, 2012 Jul. PMID 22575789, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical and morphological characterization of SEPT1 in mouse brain.
      Title: Biochemical and morphological characterization of SEPT1 in mouse brain.
    2. Results show that septin1 is a key player in spindle assembly and chromosome congression in mouse meiosis.
      Title: Septin1 is required for spindle assembly and chromosome congression in mouse oocytes.
    3. These data suggest that septins tune actomyosin forces during motility and probably regulate lymphocyte trafficking in confined tissues.
      Title: Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-1
    Names
    differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase)
    differentiation protein 6
    peanut-like protein 3
    protein Diff6
    NP_059489.2
    XP_006508092.1
    XP_006508093.1
    XP_006508094.1
    XP_011240164.1
    XP_036009143.1
    XP_036009144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017461.3 → NP_059489.2  septin-1

      See identical proteins and their annotated locations for NP_059489.2

      Status: VALIDATED

      Source sequence(s)
      AC122537
      Consensus CDS
      CCDS40141.1
      UniProtKB/Swiss-Prot
      B2RU74, P42209
      UniProtKB/TrEMBL
      A0A0U1RQA1
      Related
      ENSMUSP00000101921.2, ENSMUST00000106314.8
      Conserved Domains (2) summary
      COG5019
      Location:5 → 348
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:22 → 295
      Septin; Septin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126811881..126832157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508029.5 → XP_006508092.1  septin-1 isoform X1

      See identical proteins and their annotated locations for XP_006508092.1

      Conserved Domains (1) summary
      pfam00735
      Location:22 → 378
      Septin

    2. XM_011241862.2 → XP_011240164.1  septin-1 isoform X1

      See identical proteins and their annotated locations for XP_011240164.1

      Conserved Domains (1) summary
      pfam00735
      Location:22 → 378
      Septin

    3. XM_006508030.4 → XP_006508093.1  septin-1 isoform X2

      See identical proteins and their annotated locations for XP_006508093.1

      UniProtKB/TrEMBL
      A0A0U1RQA1, D3Z3V3
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 274
      Septin

    4. XM_036153251.1 → XP_036009144.1  septin-1 isoform X4

      Conserved Domains (1) summary
      cl40481
      Location:11 → 119
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    5. XM_006508031.4 → XP_006508094.1  septin-1 isoform X2

      See identical proteins and their annotated locations for XP_006508094.1

      UniProtKB/TrEMBL
      A0A0U1RQA1, D3Z3V3
      Related
      ENSMUSP00000101920.2, ENSMUST00000106313.8
      Conserved Domains (1) summary
      pfam00735
      Location:1 → 274
      Septin

    6. XM_036153250.1 → XP_036009143.1  septin-1 isoform X3

      Conserved Domains (1) summary
      cl40481
      Location:23 → 296
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RNA

    1. XR_003946520.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42209.2 GenPept UniProtKB/Swiss-Prot:P42209

    Gene LinkOut

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