Il11 interleukin 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il11provided by MGI
Official Full Name: interleukin 11provided by MGI
Primary source: MGI:MGI:107613
See related: Ensembl:ENSMUSG00000004371 AllianceGenome:MGI:107613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-11
Summary: Enables cytokine activity and interleukin-11 receptor binding activity. Acts upstream of or within positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in liver. Orthologous to human IL11 (interleukin 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 3.5), colon adult (RPKM 0.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.76 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4775372..4785877, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4772373..4782907, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Title: Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
Title: Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Title: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload.
Title: Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload.
Mesenchymal stromal cells protect tissues from Th1 immune responses via IL-11 secretion.
Title: Mesenchymal stromal cells protect tissues from Th1 immune responses via IL-11 secretion.
Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
Title: Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.
ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
Title: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
Title: Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
Title: Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.
Title: The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484899

U03421 (e-PCR)
- UniSTS:163406

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Il11 (e-PCR), detects polymorphism
- UniSTS:143534

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables interleukin-11 receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290423.2 → NP_001277352.1 interleukin-11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-5 all encode the same isoform (2).

Source sequence(s)

AC162034

Consensus CDS

CCDS71881.1

UniProtKB/TrEMBL

F7A7F2

Related

ENSMUSP00000131168.3, ENSMUST00000163481.3

Conserved Domains (1) summary

pfam07400
Location:2 → 140

IL11; Interleukin 11
NM_001412482.1 → NP_001399411.1 interleukin-11 isoform 2

Status: VALIDATED

Source sequence(s)

AC162034

UniProtKB/TrEMBL

F7A7F2

Related

ENSMUSP00000157240.2, ENSMUST00000234277.2
NM_001412483.1 → NP_001399412.1 interleukin-11 isoform 2

Status: VALIDATED

Source sequence(s)

AC162034

UniProtKB/TrEMBL

F7A7F2
NM_001412484.1 → NP_001399413.1 interleukin-11 isoform 2

Status: VALIDATED

Source sequence(s)

AC162034

UniProtKB/TrEMBL

F7A7F2
NM_008350.5 → NP_032376.1 interleukin-11 isoform 1 precursor

See identical proteins and their annotated locations for NP_032376.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC162034

Consensus CDS

CCDS39740.1

UniProtKB/Swiss-Prot

P47873

UniProtKB/TrEMBL

A3KPB8, Q3V0U3

Related

ENSMUSP00000092492.6, ENSMUST00000094892.12

Conserved Domains (1) summary

pfam07400
Location:23 → 199

IL11; Interleukin 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4775372..4785877 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152699.1 → XP_036008592.1 interleukin-11 isoform X1

UniProtKB/TrEMBL

F7A7F2

Conserved Domains (1) summary

pfam07400
Location:2 → 140

IL11; Interleukin 11
XM_017321988.3 → XP_017177477.1 interleukin-11 isoform X2

Conserved Domains (1) summary

pfam07400
Location:2 → 145

IL11; Interleukin 11