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    Cnbp cellular nucleic acid binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12785, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cnbpprovided by MGI
    Official Full Name
    cellular nucleic acid binding proteinprovided by MGI
    Primary source
    MGI:MGI:88431
    See related
    Ensembl:ENSMUSG00000030057 AllianceGenome:MGI:88431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf9; Cnbp1
    Summary
    Predicted to enable nucleic acid binding activity and translation regulator activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in cytosol; endoplasmic reticulum; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 105.5), liver E14 (RPKM 104.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cnbp in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87819597..87828088, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87842615..87851106, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene coatomer protein complex, subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E1704 Neighboring gene 5-hydroxymethylcytosine (hmC) binding, ES cell specific Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-quadruplex DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CCHC-type zinc finger nucleic acid binding protein
    Names
    cellular nucleic acid binding protein 1
    zinc finger protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109745.1NP_001103215.1  CCHC-type zinc finger nucleic acid binding protein isoform 2

      See identical proteins and their annotated locations for NP_001103215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AK078427, AK144740, AK159810, CJ088264
      UniProtKB/TrEMBL
      Q3U5V2
      Conserved Domains (1) summary
      PTZ00368
      Location:47165
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    2. NM_001109746.1NP_001103216.1  CCHC-type zinc finger nucleic acid binding protein isoform 3

      See identical proteins and their annotated locations for NP_001103216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (3) differs in the middle region and has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AK144740, AK151961, CJ088264
      Consensus CDS
      CCDS85092.1
      UniProtKB/TrEMBL
      Q3U935
      Related
      ENSMUSP00000109249.3, ENSMUST00000113619.8
      Conserved Domains (1) summary
      PTZ00368
      Location:47164
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    3. NM_001347325.1NP_001334254.1  CCHC-type zinc finger nucleic acid binding protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) lacks one amino acid, as compared to isoform 1.
      Source sequence(s)
      AK075760, AK144740, AK147157, CJ088264
      Consensus CDS
      CCDS85091.1
      UniProtKB/TrEMBL
      D3YYF6, Q3ULK8
      Related
      ENSMUSP00000145274.2, ENSMUST00000204653.3
      Conserved Domains (1) summary
      PTZ00368
      Location:54171
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    4. NM_001355195.1NP_001342124.1  CCHC-type zinc finger nucleic acid binding protein isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1. Isoforms 2 and 5 are the same length but have distinct sequences.
      Source sequence(s)
      AK144740, AK147157, CJ088264
      Consensus CDS
      CCDS90085.1
      UniProtKB/TrEMBL
      A0A0N4SVS6
      Related
      ENSMUSP00000145227.2, ENSMUST00000204890.3
      Conserved Domains (1) summary
      PTZ00368
      Location:48165
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    5. NM_013493.3NP_038521.1  CCHC-type zinc finger nucleic acid binding protein isoform 1

      See identical proteins and their annotated locations for NP_038521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK144740, BC058723, CJ088264
      Consensus CDS
      CCDS51841.1
      UniProtKB/Swiss-Prot
      P53996, Q80Y06, Q8BP23
      UniProtKB/TrEMBL
      Q5QJQ9
      Related
      ENSMUSP00000032138.9, ENSMUST00000032138.15
      Conserved Domains (1) summary
      PTZ00368
      Location:54172
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87819597..87828088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)