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    Ttyh3 tweety family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 78339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttyh3provided by MGI
    Official Full Name
    tweety family member 3provided by MGI
    Primary source
    MGI:MGI:1925589
    See related
    Ensembl:ENSMUSG00000036565 AllianceGenome:MGI:1925589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TTY3; mTTY3; 2900029G13Rik
    Summary
    Enables calcium ion binding activity and volume-sensitive chloride channel activity. Involved in L-glutamate transmembrane transport. Located in plasma membrane. Is expressed in retina. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 79.8), whole brain E14.5 (RPKM 56.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttyh3 in Genome Data Viewer
    Location:
    5 G2; 5 79.16 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140606332..140634826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140620577..140649071, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141072932-141073102 Neighboring gene predicted gene, 30603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene IQ motif containing E Neighboring gene STARR-positive B cell enhancer ABC_E11307 Neighboring gene BRCA1-associated ATM activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TTYH family members form tetrameric complexes at the cell membrane. Melvin E, et al. Commun Biol, 2022 Aug 30. PMID 36042377, Free PMC Article
    2. Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models. Braun J, et al. J Cyst Fibros, 2010 Sep. PMID 20624691
    3. Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization. Li B, et al. Nat Commun, 2021 Nov 25. PMID 34824283, Free PMC Article
    4. Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain. Han YE, et al. Exp Neurobiol, 2019 Apr. PMID 31138989, Free PMC Article
    5. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. He Y, et al. J Biol Chem, 2008 Aug 29. PMID 18577513, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
      Title: Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
    2. This study demonistrated that Ttyh3 gene expression in mouse dorsal raphe nucleus
      Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
    3. Down-regulation of mTTYH3 may point towards its involvement in complex cystic fibrosis pathology. However, markedly reduced expression argues against direct compensatory action as alternative anion conductance.
      Title: Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables volume-sensitive chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables volume-sensitive chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein tweety homolog 3
    Names
    tweety homolog 3
    volume-regulated anion channel subunit Ttyh3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308040.1 → NP_001294969.1  protein tweety homolog 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 2. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AI843734, BC059083, BC062917
      Consensus CDS
      CCDS80450.1
      UniProtKB/Swiss-Prot
      Q6P5F7
      Related
      ENSMUSP00000142655.2, ENSMUST00000197452.5
      Conserved Domains (1) summary
      pfam04906
      Location:25 → 430
      Tweety; Tweety

    2. NM_175274.5 → NP_780483.2  protein tweety homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_780483.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AI843734, BC062917
      Consensus CDS
      CCDS19822.1
      UniProtKB/Swiss-Prot
      Q69ZD3, Q6P5F7, Q6PCX0, Q8C789
      Related
      ENSMUSP00000037447.4, ENSMUST00000042661.8
      Conserved Domains (1) summary
      pfam04906
      Location:25 → 430
      Tweety; Tweety

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140606332..140634826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321177.2 → XP_017176666.1  protein tweety homolog 3 isoform X3

      Conserved Domains (1) summary
      pfam04906
      Location:25 → 430
      Tweety

    2. XM_030254906.2 → XP_030110766.1  protein tweety homolog 3 isoform X2

      Conserved Domains (1) summary
      pfam04906
      Location:80 → 447
      Tweety

    3. XM_030254907.2 → XP_030110767.1  protein tweety homolog 3 isoform X4

      Conserved Domains (1) summary
      pfam04906
      Location:80 → 447
      Tweety

    4. XM_030254905.2 → XP_030110765.1  protein tweety homolog 3 isoform X1

      Conserved Domains (1) summary
      pfam04906
      Location:80 → 447
      Tweety

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001308039.1: Suppressed sequence

      Description
      NM_001308039.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5F7.1 GenPept UniProtKB/Swiss-Prot:Q6P5F7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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