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    Zcchc8 zinc finger, CCHC domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 70650, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zcchc8provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 8provided by MGI
    Primary source
    MGI:MGI:1917900
    See related
    Ensembl:ENSMUSG00000029427 AllianceGenome:MGI:1917900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730565F05Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nuclear body. Predicted to be part of TRAMP complex and catalytic step 2 spliceosome. Is expressed in several structures, including blastocyst; early embryo; eye; secondary oocyte; and trunk somite. Orthologous to human ZCCHC8 (zinc finger CCHC-type containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.9), testis adult (RPKM 13.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zcchc8 in Genome Data Viewer
    Location:
    5 F; 5 63.14 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123836365..123859107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123698302..123721044, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123993667-123993967 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E2176 Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene STARR-seq mESC enhancer starr_14324 Neighboring gene predicted gene, 24840 Neighboring gene STARR-seq mESC enhancer starr_14325 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene arginine/serine-rich coiled-coil 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells. Wu Y, et al. Cell Rep, 2019 Nov 19. PMID 31747613
    2. ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. Gable DL, et al. Genes Dev, 2019 Oct 1. PMID 31488579, Free PMC Article
    3. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Kajimura S, et al. Nature, 2009 Aug 27. PMID 19641492, Free PMC Article
    4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    5. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
      Title: Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAMP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 8
    Names
    TRAMP-like complex RNA-binding factor ZCCHC8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027494.3 → NP_081770.3  zinc finger CCHC domain-containing protein 8

      See identical proteins and their annotated locations for NP_081770.3

      Status: VALIDATED

      Source sequence(s)
      AK043312, AK167126, BY090296
      Consensus CDS
      CCDS80406.1
      UniProtKB/Swiss-Prot
      Q3TK71, Q8CCB7, Q91WQ1, Q9CYA6
      UniProtKB/TrEMBL
      Q3TKH5
      Related
      ENSMUSP00000142363.2, ENSMUST00000196282.5
      Conserved Domains (2) summary
      pfam00098
      Location:230 → 247
      zf-CCHC; Zinc knuckle
      cl02643
      Location:286 → 338
      PSP; PSP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123836365..123859107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530457.1 → XP_006530520.1  zinc finger CCHC domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      smart00343
      Location:44 → 58
      ZnF_C2HC; zinc finger
      cl02643
      Location:98 → 150
      PSP

    2. XM_011248240.4 → XP_011246542.1  zinc finger CCHC domain-containing protein 8 isoform X2

      Conserved Domains (2) summary
      smart00343
      Location:12 → 26
      ZnF_C2HC; zinc finger
      cl02643
      Location:66 → 118
      PSP
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYA6.3 GenPept UniProtKB/Swiss-Prot:Q9CYA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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