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    Fam110a family with sequence similarity 110, member A [ Mus musculus (house mouse) ]

    Gene ID: 73847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam110aprovided by MGI
    Official Full Name
    family with sequence similarity 110, member Aprovided by MGI
    Primary source
    MGI:MGI:1921097
    See related
    Ensembl:ENSMUSG00000027459 AllianceGenome:MGI:1921097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700008J10Rik; 5430432M24Rik
    Summary
    Predicted to be involved in mitotic spindle organization. Located in several cellular components, including cell cortex; cytosol; and microtubule cytoskeleton. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; midbrain mantle layer; and telencephalon mantle layer. Orthologous to human FAM110A (family with sequence similarity 110 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 42.7), lung adult (RPKM 10.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam110a in Genome Data Viewer
    Location:
    2 G3; 2 74.83 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151811318..151822096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151969396..151980219, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14154 Neighboring gene microRNA 1953 Neighboring gene STARR-seq mESC enhancer starr_06034 Neighboring gene STARR-positive B cell enhancer ABC_E6000 Neighboring gene solute carrier protein family 52, member 3 Neighboring gene STARR-seq mESC enhancer starr_06039 Neighboring gene STARR-positive B cell enhancer ABC_E11171 Neighboring gene STARR-seq mESC enhancer starr_06041 Neighboring gene expressed sequence AA387200

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CK1-mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment. Aquino Perez C, et al. EMBO Rep, 2021 Jul 5. PMID 34080749, Free PMC Article
    2. Characterization of the FAM110 gene family. Hauge H, et al. Genomics, 2007 Jul. PMID 17499476
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30344

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM110A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289150.2 → NP_001276079.1  protein FAM110A

      See identical proteins and their annotated locations for NP_001276079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL845161
      Consensus CDS
      CCDS16875.1
      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4
      Related
      ENSMUSP00000105490.2, ENSMUST00000109864.8
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:8 → 104
      FAM110_N; Centrosome-associated N-terminus

    2. NM_001289151.2 → NP_001276080.1  protein FAM110A

      See identical proteins and their annotated locations for NP_001276080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL845161
      Consensus CDS
      CCDS16875.1
      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4
      Related
      ENSMUSP00000105489.2, ENSMUST00000109863.2
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:8 → 104
      FAM110_N; Centrosome-associated N-terminus

    3. NM_001406401.1 → NP_001393330.1  protein FAM110A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL845161
      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4

    4. NM_028666.4 → NP_082942.2  protein FAM110A

      See identical proteins and their annotated locations for NP_082942.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AL845161
      Consensus CDS
      CCDS16875.1
      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4
      Related
      ENSMUSP00000105491.2, ENSMUST00000109865.8
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:8 → 104
      FAM110_N; Centrosome-associated N-terminus

    5. NM_146127.4 → NP_666239.1  protein FAM110A

      See identical proteins and their annotated locations for NP_666239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL845161
      Consensus CDS
      CCDS16875.1
      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4
      Related
      ENSMUSP00000053266.6, ENSMUST00000062047.6
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:8 → 104
      FAM110_N; Centrosome-associated N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      151811318..151822096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500266.5 → XP_006500329.1  protein FAM110A isoform X2

      See identical proteins and their annotated locations for XP_006500329.1

      UniProtKB/Swiss-Prot
      Q505P3, Q8BQE5, Q8K024, Q8R184, Q8VEM7, Q9CU80
      UniProtKB/TrEMBL
      G4XVC4
      Conserved Domains (2) summary
      pfam14160
      Location:183 → 288
      FAM110_C; Centrosome-associated C-terminus
      pfam14161
      Location:8 → 104
      FAM110_N; Centrosome-associated N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R184.2 GenPept UniProtKB/Swiss-Prot:Q8R184

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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