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    Zfp442 zinc finger protein 442 [ Mus musculus (house mouse) ]

    Gene ID: 668923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp442provided by MGI
    Official Full Name
    zinc finger protein 442provided by MGI
    Primary source
    MGI:MGI:3651999
    See related
    Ensembl:ENSMUSG00000068130 AllianceGenome:MGI:3651999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZIPO-II
    Summary
    Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF28 (zinc finger protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp442 in Genome Data Viewer
    Location:
    2 G3; 2 74.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150244400..150293421, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150402480..150451501, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3300002I08 gene Neighboring gene STARR-positive B cell enhancer ABC_E1012 Neighboring gene zinc finger protein 1001 Neighboring gene STARR-positive B cell enhancer ABC_E7866 Neighboring gene predicted gene 14122 Neighboring gene STARR-seq mESC enhancer starr_06004 Neighboring gene methyltransferase-like protein 23 Neighboring gene zinc finger protein 345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC38507

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 442
    Names
    zinc-finger protein in podocyte II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310645.1 → NP_001297574.1  zinc finger protein 442

      See identical proteins and their annotated locations for NP_001297574.1

      Status: VALIDATED

      Source sequence(s)
      AB470967, AL935313
      Consensus CDS
      CCDS79853.1
      UniProtKB/TrEMBL
      A2AQA0
      Related
      ENSMUSP00000105542.2, ENSMUST00000109916.8
      Conserved Domains (5) summary
      smart00349
      Location:4 → 57
      KRAB; krueppel associated box
      COG5048
      Location:209 → 589
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213 → 233
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:225 → 250
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150244400..150293421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239742.4 → XP_011238044.1  zinc finger protein 442 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:177 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:539 → 622
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:181 → 201
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011239741.2 → XP_011238043.1  zinc finger protein 442 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:215 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:577 → 660
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:10 → 50
      KRAB; KRAB box

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177550.1: Suppressed sequence

      Description
      NM_001177550.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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