Slc22a6 solute carrier family 22 (organic anion transporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a6provided by MGI
Official Full Name: solute carrier family 22 (organic anion transporter), member 6provided by MGI
Primary source: MGI:MGI:892001
See related: Ensembl:ENSMUSG00000024650 AllianceGenome:MGI:892001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NKT; Oat1; mOat1; Orctl1
Summary: Enables antiporter activity and organic anion transmembrane transporter activity. Involved in organic anion transport and renal tubular secretion. Acts upstream of or within monoatomic anion transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human SLC22A6 (solute carrier family 22 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward kidney adult (RPKM 141.9) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.44 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8595360..8605663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8617996..8628299)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis.
Title: Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis.
The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism.
Title: The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism.
Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.
Title: Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.
A key role for the transporter OAT1 in systemic lipid metabolism.
Title: A key role for the transporter OAT1 in systemic lipid metabolism.
Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
Title: Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3.
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Title: Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.
Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
Title: Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).
Title: Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
It is the key assembly for uric acid secretion through kidney.
Title: Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.
OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.
Title: Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc22a6 (e-PCR), detects polymorphism
- UniSTS:463373

Drp2 (e-PCR), detects polymorphism
- UniSTS:142870

BB361134 (e-PCR)
- UniSTS:209433

U52842 (e-PCR)
- UniSTS:125769

Slc22a6 (e-PCR), detects polymorphism
- UniSTS:496052

Slc22a6 (e-PCR), detects polymorphism
- UniSTS:545992

Slc22a6 (e-PCR), detects polymorphism
- UniSTS:144089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-ketoglutarate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	IEA Inferred from Electronic Annotation more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in alpha-ketoglutarate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inorganic anion transport	IEA Inferred from Electronic Annotation more info
involved_in metanephric proximal tubule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic anion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organic anion transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organic anion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal tubular secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal tubular secretion	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 6

Names: kidney-specific transport protein; mNKT; mROAT1; novel kidney transcript; organic anion transporter 1; organic cationic transporter-like 1; renal organic anion transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008766.3 → NP_032792.2 solute carrier family 22 member 6

See identical proteins and their annotated locations for NP_032792.2

Status: VALIDATED

Source sequence(s)

AC025794, AK035971

Consensus CDS

CCDS29538.1

UniProtKB/Swiss-Prot

Q61185, Q8VC69

Related

ENSMUSP00000010250.3, ENSMUST00000010250.4

Conserved Domains (2) summary

cd06174
Location:129 → 499

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 509

2A0119; cation transport protein