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    Ciao3 cytosolic iron-sulfur assembly component 3 [ Mus musculus (house mouse) ]

    Gene ID: 67563, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ciao3provided by MGI
    Official Full Name
    cytosolic iron-sulfur assembly component 3provided by MGI
    Primary source
    MGI:MGI:1914813
    See related
    Ensembl:ENSMUSG00000002280 AllianceGenome:MGI:1914813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRN; Narfl; 9030612I22Rik
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 17.3), cerebellum adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ciao3 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.88 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25992750..26002306)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25773776..25783332)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, et al. J Biol Chem, 2011 May 6. PMID 21367862, Free PMC Article
    2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    3. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular oxygen homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular oxygen homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic iron-sulfur assembly component 3
    Names
    IOP1
    cytosolic Fe-S cluster assembly factor NARFL
    iron-only hydrogenase-like protein 1
    nuclear prelamin A recognition factor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026238.4 → NP_080514.3  cytosolic iron-sulfur assembly component 3

      See identical proteins and their annotated locations for NP_080514.3

      Status: VALIDATED

      Source sequence(s)
      AK018548, AK043694, AK145408
      Consensus CDS
      CCDS50034.1
      UniProtKB/Swiss-Prot
      Q3ULM7, Q7TMW6, Q8BRR3, Q9CXS6, Q9D320
      Related
      ENSMUSP00000002350.5, ENSMUST00000002350.11
      Conserved Domains (3) summary
      smart00902
      Location:418 → 466
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:58 → 462
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:110 → 405
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25992750..26002306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524828.5 → XP_006524891.1  cytosolic iron-sulfur assembly component 3 isoform X1

      UniProtKB/TrEMBL
      A0A494BA87
      Related
      ENSMUSP00000157987.2, ENSMUST00000237541.2
      Conserved Domains (1) summary
      pfam02906
      Location:112 → 358
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    2. XM_006524829.4 → XP_006524892.1  cytosolic iron-sulfur assembly component 3 isoform X2

      Conserved Domains (2) summary
      smart00902
      Location:200 → 248
      Fe_hyd_SSU; Iron hydrogenase small subunit
      pfam02906
      Location:1 → 185
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMW6.2 GenPept UniProtKB/Swiss-Prot:Q7TMW6

    Gene LinkOut

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