Pkd1 polycystin 1, transient receptor potential channel interacting [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pkd1provided by MGI
Official Full Name: polycystin 1, transient receptor potential channel interactingprovided by MGI
Primary source: MGI:MGI:97603
See related: Ensembl:ENSMUSG00000032855 AllianceGenome:MGI:97603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC1; mFLJ00285
Summary: Enables calcium channel activity and transcription regulator inhibitor activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; placenta blood vessel development; and protein export from nucleus. Acts upstream of or within several processes, including cartilage condensation; circulatory system development; and regulation of mitotic spindle organization. Located in several cellular components, including Golgi apparatus; cell surface; and motile cilium. Part of polycystin complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Used to study autosomal recessive polycystic kidney disease; hypertrophic cardiomyopathy; and polycystic kidney disease 1. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 37.1), lung adult (RPKM 32.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.4 cM

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24767657..24815457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24548689..24596514)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD.
Title: Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD.
Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healing.
Title: Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healing.
Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction.
Title: Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction.
Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.
Title: Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.
Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
Title: Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.
Title: Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.
In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model.
Title: In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model.
Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy.
Title: Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy.
Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders.
Title: Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders.
PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
Title: PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.

Submit: New GeneRIF Correction See all GeneRIFs (152)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (6)
Targeted (33) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pkd1 (e-PCR), detects polymorphism
- UniSTS:531218

Pkd1 (e-PCR), detects polymorphism
- UniSTS:536440

Pkd1 (e-PCR), detects polymorphism
- UniSTS:536441

Pkd1 (e-PCR), detects polymorphism
- UniSTS:526977

Tsc2 (e-PCR), detects polymorphism
- UniSTS:265680

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription regulator inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in lymph vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
involved_in branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genitalia development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lung epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephric duct development	IEA Inferred from Electronic Annotation more info
involved_in metanephric ascending thin limb development	IEA Inferred from Electronic Annotation more info
involved_in metanephric collecting duct development	IEA Inferred from Electronic Annotation more info
involved_in metanephric distal tubule morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in metanephric proximal tubule development	IEA Inferred from Electronic Annotation more info
involved_in mitocytosis	ISO Inferred from Sequence Orthology more info
involved_in mitocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nitrogen cycle metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin development	IEA Inferred from Electronic Annotation more info
involved_in spinal cord development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in migrasome	ISO Inferred from Sequence Orthology more info
located_in migrasome	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of polycystin complex	IDA Inferred from Direct Assay more info	PubMed
part_of polycystin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of polycystin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycystin-1

Names: autosomal dominant polycystic kidney disease 1 protein homolog; polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystin 1, transient receptor poteintial channel interacting

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013630.3 → NP_038658.2 polycystin-1 precursor

See identical proteins and their annotated locations for NP_038658.2

Status: VALIDATED

Source sequence(s)

AC132367

Consensus CDS

CCDS28485.1

UniProtKB/Swiss-Prot

E9QJR6, O08852

Related

ENSMUSP00000049296.4, ENSMUST00000035565.5

Conserved Domains (14) summary

cd00037
Location:418 → 530

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

TIGR00864
Location:97 → 2723

PCC; polycystin cation channel protein

smart00303
Location:3003 → 3052

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:125 → 177

LRRCT; Leucine rich repeat C-terminal domain

smart00089
Location:1485 → 1539

PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

smart00321
Location:177 → 271

WSC; present in yeast cell wall integrity and stress response component proteins

cd00146
Location:1290 → 1371

PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

cd01752
Location:3110 → 3229

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam00801
Location:1720 → 1789

PKD; PKD domain

pfam08016
Location:3701 → 4103

PKD_channel; Polycystin cation channel

pfam12799
Location:72 → 108

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:61 → 127

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24767657..24815457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523841.5 → XP_006523904.1 polycystin-1 isoform X8

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3711 → 4112

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249577.2 → XP_030105437.1 polycystin-1 isoform X2

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3724 → 4125

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523842.5 → XP_006523905.1 polycystin-1 isoform X9

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3710 → 4111

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249584.2 → XP_030105444.1 polycystin-1 isoform X16

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3687 → 4088

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249586.2 → XP_030105446.1 polycystin-1 isoform X18

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3673 → 4074

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249585.2 → XP_030105445.1 polycystin-1 isoform X17

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3686 → 4087

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523852.5 → XP_006523915.1 polycystin-1 isoform X19

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00303
Location:3011 → 3060

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3672 → 4073

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249581.2 → XP_030105441.1 polycystin-1 isoform X6

Conserved Domains (7) summary

TIGR00864
Location:97 → 2725

PCC; polycystin cation channel protein

smart00303
Location:3005 → 3054

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3112 → 3231

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3719 → 4120

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523843.4 → XP_006523906.1 polycystin-1 isoform X10

Conserved Domains (7) summary

TIGR00864
Location:97 → 2725

PCC; polycystin cation channel protein

smart00303
Location:3005 → 3054

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3112 → 3231

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3705 → 4106

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523844.4 → XP_006523907.1 polycystin-1 isoform X11

Conserved Domains (7) summary

TIGR00864
Location:97 → 2725

PCC; polycystin cation channel protein

smart00303
Location:3005 → 3054

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3112 → 3231

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3704 → 4105

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_036160406.1 → XP_036016299.1 polycystin-1 isoform X20

Conserved Domains (7) summary

TIGR00864
Location:97 → 2725

PCC; polycystin cation channel protein

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3112 → 3231

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3667 → 4067

PKD_channel; Polycystin cation channel

pfam13855
Location:61 → 127

LRR_8; Leucine rich repeat

cl02559
Location:3005 → 3054

GPS; GPCR proteolysis site, GPS, motif
XM_030249579.2 → XP_030105439.1 polycystin-1 isoform X4

Conserved Domains (7) summary

TIGR00864
Location:97 → 2729

PCC; polycystin cation channel protein

smart00303
Location:3009 → 3058

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3116 → 3235

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3723 → 4124

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523845.4 → XP_006523908.1 polycystin-1 isoform X12

Conserved Domains (7) summary

TIGR00864
Location:97 → 2723

PCC; polycystin cation channel protein

smart00303
Location:3003 → 3052

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3110 → 3229

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3703 → 4104

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249578.2 → XP_030105438.1 polycystin-1 isoform X3

Conserved Domains (7) summary

TIGR00864
Location:97 → 2730

PCC; polycystin cation channel protein

smart00303
Location:3010 → 3059

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3117 → 3236

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3724 → 4125

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249580.2 → XP_030105440.1 polycystin-1 isoform X5

Conserved Domains (7) summary

TIGR00864
Location:97 → 2728

PCC; polycystin cation channel protein

smart00303
Location:3008 → 3057

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3115 → 3234

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3722 → 4123

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249582.2 → XP_030105442.1 polycystin-1 isoform X7

Conserved Domains (7) summary

TIGR00864
Location:97 → 2722

PCC; polycystin cation channel protein

smart00303
Location:3002 → 3051

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3109 → 3228

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3716 → 4117

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523846.4 → XP_006523909.1 polycystin-1 isoform X13

Conserved Domains (7) summary

TIGR00864
Location:97 → 2722

PCC; polycystin cation channel protein

smart00303
Location:3002 → 3051

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3109 → 3228

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3702 → 4103

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_006523847.4 → XP_006523910.1 polycystin-1 isoform X14

Conserved Domains (7) summary

TIGR00864
Location:97 → 2722

PCC; polycystin cation channel protein

smart00303
Location:3002 → 3051

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3109 → 3228

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3701 → 4102

PKD_channel; Polycystin cation channel

pfam12799
Location:61 → 108

LRR_4; Leucine Rich repeats (2 copies)
XM_030249583.2 → XP_030105443.1 polycystin-1 isoform X15

Conserved Domains (6) summary

TIGR00864
Location:73 → 2707

PCC; polycystin cation channel protein

smart00303
Location:2987 → 3036

GPS; G-protein-coupled receptor proteolytic site domain

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3094 → 3213

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:63 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3701 → 4102

PKD_channel; Polycystin cation channel
XM_036160405.1 → XP_036016298.1 polycystin-1 isoform X1

Conserved Domains (7) summary

TIGR00864
Location:97 → 2731

PCC; polycystin cation channel protein

smart00013
Location:32 → 71

LRRNT; Leucine rich repeat N-terminal domain

cd01752
Location:3118 → 3237

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

sd00031
Location:70 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam08016
Location:3726 → 4126

PKD_channel; Polycystin cation channel

pfam13855
Location:61 → 127

LRR_8; Leucine rich repeat

cl02559
Location:3011 → 3060

GPS; GPCR proteolysis site, GPS, motif
XM_030249589.1 → XP_030105449.1 polycystin-1 isoform X23

Conserved Domains (4) summary

TIGR00864
Location:1 → 1720

PCC; polycystin cation channel protein

smart00303
Location:2000 → 2049

GPS; G-protein-coupled receptor proteolytic site domain

cd01752
Location:2107 → 2226

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam08016
Location:2714 → 3115

PKD_channel; Polycystin cation channel
XM_030249587.1 → XP_030105447.1 polycystin-1 isoform X21

Conserved Domains (4) summary

TIGR00864
Location:3 → 2416

PCC; polycystin cation channel protein

smart00303
Location:2696 → 2745

GPS; G-protein-coupled receptor proteolytic site domain

cd01752
Location:2803 → 2922

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam08016
Location:3410 → 3811

PKD_channel; Polycystin cation channel
XM_030249588.1 → XP_030105448.1 polycystin-1 isoform X22

Conserved Domains (4) summary

TIGR00864
Location:3 → 2415

PCC; polycystin cation channel protein

smart00303
Location:2695 → 2744

GPS; G-protein-coupled receptor proteolytic site domain

cd01752
Location:2802 → 2921

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam08016
Location:3409 → 3810

PKD_channel; Polycystin cation channel